Podrid P J
Drugs. 1985;29 Suppl 4:33-44. doi: 10.2165/00003495-198500294-00009.
Each antiarrhythmic agent can cause side effects, but most of these are easily recognised by the patient or physician. However, one potentially serious side effect common to all of these drugs is aggravation of ventricular arrhythmia. Often this is without symptoms and goes unrecognised by the patient. It occurs in 11 to 16% of drug tests depending upon the method of drug evaluation employed. There are no ECG changes which predict its occurrence and blood concentrations of drug are usually within a therapeutic range. There are no clinical patient features which are associated with this toxic reaction and it does not correlate with the presence or extent of underlying heart disease, the nature of the presenting arrhythmia or the known electrophysiological properties of the antiarrhythmic drug. Careful evaluation of these drugs is therefore essential.
每种抗心律失常药物都可能引起副作用，但大多数副作用患者或医生都能轻易识别。然而，所有这些药物都有一个潜在的严重副作用，即室性心律失常加重。这种情况通常没有症状，患者也未察觉。根据所采用的药物评估方法，在11%至16%的药物试验中会出现这种情况。没有可预测其发生的心电图变化，药物血药浓度通常在治疗范围内。没有与这种毒性反应相关的临床患者特征，它与潜在心脏病的存在或程度、所呈现心律失常的性质或抗心律失常药物已知的电生理特性均无关联。因此，对这些药物进行仔细评估至关重要。
