Department of Neurosurgery, Kyoto University Graduate School of Medicine.
Moyamoya Disease Support Center, Kyoto University Hospital.
Neurol Med Chir (Tokyo). 2024 Oct 15;64(10):376-381. doi: 10.2176/jns-nmc.2024-0063. Epub 2024 Sep 7.
Recent cohort studies on hemorrhagic and asymptomatic moyamoya disease have revealed that choroidal anastomosis, a type of fragile periventricular collateral pathway (periventricular anastomosis) typical of the disease, is an independent predictor of hemorrhagic stroke. However, treatment strategies for less-symptomatic nonhemorrhagic patients with choroidal anastomosis remain unclear. The Moyamoya Periventricular Choroidal Collateral (P-ChoC) Registry is an ongoing multicentered observational study that will test the hypothesis that extracranial-intracranial bypass prevents de novo hemorrhagic stroke in less symptomatic, nonhemorrhagic patients with choroidal anastomosis and may thus contribute to improving the prognosis of moyamoya disease. In this study, we report the study protocol of the moyamoya P-ChoC Registry and review the literature on choroidal anastomosis as a fragile collateral pathway.
最近关于出血性和无症状性烟雾病的队列研究表明，脉络膜吻合，一种典型的疾病脆弱的脑室周围侧支途径（脑室周围吻合），是出血性卒中的独立预测因子。然而，对于脉络膜吻合的症状较轻的非出血性患者的治疗策略仍不清楚。烟雾病脑室周围脉络膜侧支（P-ChoC）注册研究是一项正在进行的多中心观察性研究，旨在验证以下假设：颅内外旁路可以预防症状较轻的、有脉络膜吻合的非出血性患者发生新的出血性卒中，从而改善烟雾病的预后。在本研究中，我们报告了烟雾病 P-ChoC 注册研究的研究方案，并回顾了脉络膜吻合作为一种脆弱的侧支途径的文献。
