Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.
Expert Opin Drug Deliv. 2024 Aug;21(8):1251-1262. doi: 10.1080/17425247.2024.2400293. Epub 2024 Sep 8.
Polymeric nanoparticles used for antigen delivery against infections and for cancer immunotherapy are an emerging therapeutic strategy in promoting the development of innovative vaccines. Beyond their capability to create targeted delivery systems with controlled release of payloads, biodegradable polymers are utilized for their ability to enhance the immunogenicity and stability of antigens.
This review extensively discusses the physicochemical parameters that affect the behavior of nanoparticles as antigen-delivery systems. Additionally, various types of natural and synthetic polymers and recent advancements in nanoparticle-based targeted vaccine production are reviewed.
Biodegradable polymeric nanoparticles have gained major interest in the vaccination filed and have been extensively used to encapsulate antigens against a wide variety of tumors. Moreover, their versatility in terms of tunning their physicochemical characteristics, and their surface, facilitates the targeting to antigen presenting cells and enhances immune response.
用于传递抗原以对抗感染和癌症免疫治疗的聚合物纳米颗粒是一种新兴的治疗策略，可促进创新疫苗的发展。除了能够创建具有受控释放有效载荷的靶向递送系统之外，可生物降解聚合物还因其能够增强抗原的免疫原性和稳定性而被利用。
本文广泛讨论了影响纳米颗粒作为抗原递送系统行为的物理化学参数。此外，还综述了各种类型的天然和合成聚合物以及基于纳米颗粒的靶向疫苗生产的最新进展。
可生物降解聚合物纳米颗粒在疫苗领域引起了广泛关注，并已被广泛用于封装针对各种肿瘤的抗原。此外，它们在调整物理化学特性及其表面方面的多功能性，有利于靶向抗原呈递细胞并增强免疫反应。
