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苦杏仁提取物的镇痛、抗氧化、抗炎及伤口治疗作用

Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract.

作者信息

El-Hajjaji Mohamed Amine, Fikri-Benbrahim Kawtar, Soulo Najoua, Nouioura Ghizlane, Laaroussi Hassan, Ferreira-Santos Pedro, Lyoussi Badiaa, Benziane Ouaritini Zineb

机构信息

Laboratory of Natural Substances, Pharmacology, Environment, Modeling Health and Quality of Life Faculty of Sciences Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.

Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty Sidi Mohamed Ben Abdellah University, P.O. Box 2202, Imouzzer Road, Fez, Morocco.

出版信息

Adv Pharmacol Pharm Sci. 2024 Aug 31;2024:5574259. doi: 10.1155/2024/5574259. eCollection 2024.

DOI:10.1155/2024/5574259
PMID:39246415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380719/
Abstract

Apricot ( L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bitter apricot kernels (BAK). Obtained results indicated that the BAK extract presents a content of 4.58 ± 0.15 mg GAE/g extract of TPA and 1.68 ± 0.09 mg QUE/g extract of TFA, respectively. HPLC-ESI-MS analysis discovered the presence of 17 phenolic compounds including phenolic acids and flavonoids like 3,4-dihydroxybenzoic acid, gallic acid, caffeic acid, (+)-catechin, epicatechin, and others, with associated antioxidant power. Regarding the studied potential pharmacological effects, notable analgesic activity at a dosage of 100 mg/kg BW was recorded with 63.46% protection. In the anti-inflammatory test, significant inhibition was observed after 6 hours of treatment (77.4%) compared to untreated animals. Moreover, the daily application of ointment formulated with 10% BAK extract resulted in a remarkable healing of wounds and burns in rats. These findings underscore the increasing evidence supporting the potential use of apricot kernel extracts in treating various diseases.

摘要

苦杏仁（L.）核已被广泛应用于植物医学中治疗各种疾病。本研究旨在通过高效液相色谱 - 电喷雾质谱法揭示其植物化学成分、抗氧化活性，并研究苦杏仁核水乙醇提取物（BAK）的某些药理作用。所得结果表明，BAK提取物的总酚含量为4.58±0.15毫克没食子酸当量/克提取物，总黄酮含量为1.68±0.09毫克芦丁/克提取物。高效液相色谱 - 电喷雾质谱分析发现存在17种酚类化合物，包括酚酸和黄酮类化合物，如3,4 - 二羟基苯甲酸、没食子酸、咖啡酸、（+） - 儿茶素、表儿茶素等，并具有相关的抗氧化能力。关于所研究的潜在药理作用，在剂量为100毫克/千克体重时记录到显著的镇痛活性，保护率为63.46%。在抗炎试验中，与未治疗的动物相比，治疗6小时后观察到显著的抑制作用（77.4%）。此外，每日应用含10% BAK提取物的软膏可使大鼠的伤口和烧伤显著愈合。这些发现强调了越来越多的证据支持杏仁核提取物在治疗各种疾病中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/5a3b0fc0ce87/APS2024-5574259.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/0c98d32fdf52/APS2024-5574259.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/54baf00bed69/APS2024-5574259.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/68b33495bba5/APS2024-5574259.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/5a3b0fc0ce87/APS2024-5574259.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/0c98d32fdf52/APS2024-5574259.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/54baf00bed69/APS2024-5574259.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/68b33495bba5/APS2024-5574259.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c79/11380719/5a3b0fc0ce87/APS2024-5574259.004.jpg

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A Review with Updated Perspectives on Nutritional and Therapeutic Benefits of Apricot and the Industrial Application of Its Underutilized Parts.
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