Jacques M, Turgeon P L, Mathieu L G, de Repentigny J
Exp Biol. 1985;43(4):251-6.
The effect of subminimal inhibitory concentrations (subMICs) of six commonly used antibiotics on adherence of Neisseria gonorrhoeae to rabbit mesentery was studied. We found that, at 1/2 MIC, ampicillin, cefoxitin and penicillin G decreased adherence of gonococci by more than 65%, and erythromycin by approximately 40%; doxycycline and tetracycline had no appreciable effect. Results suggest that subMICs of some antibiotics could affect interactions of gonococci with some mammalian cells, more specifically adherence, a critical step in the pathogenesis of an infection.
研究了六种常用抗生素的亚最小抑菌浓度（subMICs）对淋病奈瑟菌黏附兔肠系膜的影响。我们发现，在1/2 MIC时，氨苄西林、头孢西丁和青霉素G使淋球菌的黏附减少了65%以上，红霉素使黏附减少了约40%；强力霉素和四环素没有明显影响。结果表明，某些抗生素的亚最小抑菌浓度可能会影响淋球菌与某些哺乳动物细胞的相互作用，更具体地说是黏附，这是感染发病机制中的关键一步。
