The Danish Research Unit for Hospital Pharmacy, Amgros I/S, Dampfærgevej 22, 2100, Copenhagen Ø, Denmark,
Int J Clin Pharm. 2014 Aug;36(4):734-41. doi: 10.1007/s11096-014-9939-4. Epub 2014 Apr 16.
In 2010, a database of drug related problems (DRPs) was implemented to assist clinical pharmacy staff in documenting clinical pharmacy activities locally. A study of quality, reliability and generalisability showed that national analyses of the data could be conducted. Analyses at the national level may help identify and prevent DRPs by performing national interventions.
The aim of the study was to explore the DRP characteristics as documented by clinical pharmacy staff at hospital pharmacies in the Danish DRP-database during a 3-year period.
Danish hospital pharmacies.
Data documented in the DRP-database during the initial 3 years after implementation were analyzed retrospectively. The DRP-database contains DRPs reported at hospitals by clinical pharmacy staff. The analyses focused on DRP categories, implementation rates and drugs associated with the DRPs.
Characteristics of DRPs.
In total, 72,044 DRPs were documented in the DRP-database during the first 3 years of implementation, and the number of documented DRPs increased every year. An overall stable implementation rate of approximately 58 % was identified. The DRPs identified were multi-facetted, however evenly distributed for each of the 3 years. The most frequently identified DRP categories were: "Dose", followed by "Nonadherence to guidelines" and "Supplement to treatment". The highest implementation rates were found for the following DRP categories: "Non-adherence to guidelines" (79 %) followed by "Therapeutic duplication" (73 %) and "Dosing time and interval" (70 %). Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The drugs most frequently involved in DRPs were paracetamol (4.6 % of all DRPs), simvastatin (3.0 %), lansoprazole (2.7 %), morphine (2.6 %) and alendronic acid (2.4 %).
The study found that a national database on DRPs contained multi-facetted DRPs, however evenly distributed for each of the 3 years. Even though the top 25 drugs were involved in 58 % of all DRPs, multiple drugs were associated with DRPs. The study emphasizes the importance of detecting and intervening for DRPs.
2010 年，建立了一个药物相关问题（DRP）数据库，以协助临床药师在当地记录临床药学活动。一项关于质量、可靠性和可推广性的研究表明，可以进行全国范围内的数据分析。在全国范围内进行分析可以通过实施全国性干预措施来帮助识别和预防 DRP。
本研究旨在探讨丹麦 DRP 数据库中临床药师在 3 年内记录的 DRP 特征。
丹麦医院药房。
回顾性分析实施后最初 3 年内 DRP 数据库中记录的数据。DRP 数据库包含临床药师在医院报告的 DRP。分析侧重于 DRP 类别、实施率和与 DRP 相关的药物。
DRP 特征。
在实施后的头 3 年中，共在 DRP 数据库中记录了 72044 个 DRP，记录的 DRP 数量逐年增加。确定了一个总体稳定的实施率约为 58%。确定的 DRP 是多方面的，但 3 年来分布均匀。最常被识别的 DRP 类别是：“剂量”，其次是“不遵守指南”和“治疗补充”。实施率最高的是以下 DRP 类别：“不遵守指南”（79%），其次是“治疗重复”（73%）和“剂量时间和间隔”（70%）。尽管前 25 种药物占所有 DRP 的 58%，但多种药物与 DRP 有关。与 DRP 最常相关的药物是对乙酰氨基酚（所有 DRP 的 4.6%）、辛伐他汀（3.0%）、兰索拉唑（2.7%）、吗啡（2.6%）和阿仑膦酸钠（2.4%）。
该研究发现，国家 DRP 数据库包含多方面的 DRP，但 3 年来分布均匀。尽管前 25 种药物占所有 DRP 的 58%，但多种药物与 DRP 有关。该研究强调了检测和干预 DRP 的重要性。
