Department of Endocrine and Metabolic Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Endocrinol (Lausanne). 2024 Aug 23;15:1411262. doi: 10.3389/fendo.2024.1411262. eCollection 2024.
Under the current pandemic of Corona Virus Disease 2019 (COVID-19), The relationship between fatigue and COVID-19 has been found. Infection with COVID-19 is associated with fatigue long after the acute phase of COVID-19. Understanding the association of thyroid hormones levels with post-COVID condition, such as fatigue, is necessary to improve quality of life.
This population-based cohort study was conducted in Dalian, China, from December 2022, to March 2023, using a Yidu Core platform in the First Affiliated Hospital of Dalian Medical University, that integrates medical records, laboratory tests, and all diagnosis and treatment information based on patients in hospital. Eligible individuals were 40 patients with COVID-19, Divided them into fatigue group and non-fatigue group following up by telephone using the FS-14 scale after 6 months. The primary outcomes were the diagnoses of fatigue. The association between thyroid hormones levels and post-COVID condition, such as fatigue, was assessed using logistic regression analysis.
Compared with the non-fatigue group, the FT level in fatigue group was lower (<0.05). FT was negatively correlated with fatigue after 6 months ( 0.257, <0.05). After adjusting for confounding factors such as age and gender, low FT was a risk factor for fatigue in patients with COVID-19, ( 0.225, <0.05). And the FT is less than 2.47 mol/L, it is the best critical value for predicting long-term fatigue, with a sensitivity of 92.3% and a specificity of 48.1%.
Most people still have fatigue 6 months after COVID-19 infection. FT serves as the important index to predict fatigue in patients with COVID-19. it should be closely monitored during infection.
在当前 2019 年冠状病毒病（COVID-19）大流行下，已经发现疲劳与 COVID-19 之间存在关系。感染 COVID-19 与 COVID-19 急性阶段后长时间的疲劳有关。了解甲状腺激素水平与 COVID-19 后状况（如疲劳）的关联对于提高生活质量是必要的。
这项基于人群的队列研究于 2023 年 3 月在中国大连进行，使用大连医科大学第一附属医院的 Yidu Core 平台，该平台整合了基于医院患者的病历、实验室检查和所有诊断和治疗信息。合格的个体为 40 名 COVID-19 患者，根据 FS-14 量表在 6 个月后通过电话将他们分为疲劳组和非疲劳组。主要结局是疲劳的诊断。使用逻辑回归分析评估甲状腺激素水平与 COVID-19 后状况（如疲劳）之间的关联。
与非疲劳组相比，疲劳组的 FT 水平较低（<0.05）。FT 与 6 个月后的疲劳呈负相关（0.257，<0.05）。在校正年龄和性别等混杂因素后，低 FT 是 COVID-19 患者疲劳的危险因素（0.225，<0.05）。FT 小于 2.47 mol/L 时，是预测长期疲劳的最佳临界值，敏感性为 92.3%，特异性为 48.1%。
大多数人在 COVID-19 感染后 6 个月仍有疲劳。FT 是预测 COVID-19 患者疲劳的重要指标。在感染期间应密切监测。
