体内阴道抗真菌制剂的评估。
Evaluation of vaginal antifungal formulations in vivo.
作者信息
McRipley R J, Erhard P J, Schwind R A, Whitney R R
出版信息
Postgrad Med J. 1979 Sep;55(647):648-52. doi: 10.1136/pgmj.55.647.648.
Abstract
Relatively simple and rapid procedures have been developed for evaluating the local efficacy of vaginal antifungal agents in vivo in a vaginal candidiasis model in ovariectomized rats. The results of this investigation indicate that the model and methods described are quite suitable for screening potential antifungal substances and for assessing the chemotherapeutic effectiveness of new antifungal agents and formulations before carrying out clinical studies.
摘要
已经开发出相对简单快速的程序，用于在去卵巢大鼠的阴道念珠菌病模型中体内评估阴道抗真菌剂的局部疗效。本研究结果表明，所描述的模型和方法非常适合在进行临床研究之前筛选潜在的抗真菌物质，以及评估新型抗真菌剂和制剂的化疗效果。
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本文引用的文献
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[Chemotherapy of vaginal trichomoniasis and candidiasis in mice].[小鼠阴道滴虫病和念珠菌病的化学疗法]
Arzneimittelforschung. 1974 Jun;24(6):937-43.
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Synergism of polyene antibiotics with 5-fluorocytosine.多烯抗生素与5-氟胞嘧啶的协同作用。
Chemotherapy. 1978;24(1):2-16. doi: 10.1159/000237753.
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