Sobel J D, Muller G
Antimicrob Agents Chemother. 1983 Sep;24(3):434-6. doi: 10.1128/AAC.24.3.434.
The efficacies of ketoconazole and two new imidazole preparations, Bay N7133 and Bay L9139, were compared in a rat model of experimental candida vaginitis. With a dosage regimen of 10 mg/kg by gavage for 5 days, the cure rate for ketoconazole was 96% as compared with rates of 23 and 29% for Bay N7133 and Bay L9139, respectively (P less than 0.001). Follow-up vaginal cultures at 30 days revealed a relapse in only 1 of 27 rats treated with ketoconazole. Our subsequent experiment in which ketoconazole regimens of 10 mg/kg were compared with Bay N7133 and Bay L9139 regimens of 25 mg/kg demonstrated cure rates of 100, 15, and 82% for the respective agents.
在实验性念珠菌阴道炎大鼠模型中，比较了酮康唑与两种新型咪唑制剂（Bay N7133和Bay L9139）的疗效。采用10mg/kg灌胃给药5天的方案，酮康唑的治愈率为96%，而Bay N7133和Bay L9139的治愈率分别为23%和29%（P<0.001）。30天的后续阴道培养显示，用酮康唑治疗的27只大鼠中只有1只复发。我们随后进行的实验中，将10mg/kg的酮康唑方案与25mg/kg的Bay N7133和Bay L9139方案进行比较，结果显示各药物的治愈率分别为100%、15%和82%。
