Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT.
Department of Ophthalmology, Ambroise Paré Hospital, IHU FOReSIGHT, AP-HP, University of Paris Saclay, Boulogne-Billancourt.
J Glaucoma. 2024 Dec 1;33(12):957-963. doi: 10.1097/IJG.0000000000002494. Epub 2024 Sep 11.
The lamina cribrosa (LC) pores of patients with high-tension glaucoma (HTG) appear to take a more tortuous pathway than the LC pores of patients with non-glaucomatous (NG).
To compare the LC pore microarchitecture in patients with HTG, normal tension glaucoma (NTG), and NG, by reconstructions of the LC made from tomographic images.
Spectral domain-optical coherence tomography images of 52 eyes (18 NG, 18 HTG, and 16 NTG) of 29 patients were analyzed. Pores were traced using segmentation software. Pore length, tortuosity, and verticality were the 3 quantitative parameters compared among the 3 groups. Correlation analyses were performed to determine the effects of covariates on the 3 quantitative parameters.
Pore tortuosity in HTG (1.419 ± 0.093) was significantly higher ( P = 0.011) than in NG (1.347 ± 0,034) but did not differ from that of NTG eyes ( P = 0.251). In addition, NTG had significantly shorter pores ( P = 0.005) than NG. No difference in pore tortuosity or verticality was found between NG and NTG ( P = 0.587 and P = 0.120, respectively). Pore verticality and length in HTG eyes did not significantly differ from that of NG eyes ( P = 0.049 and P = 0.033, respectively) and NTG eyes ( P = 0.827 and P = 0.968, respectively). All of the quantitative parameters measured were not correlated with age but were associated with glaucoma severity (Visual Field Index, mean deviation, retinal nerve fiber layer, and ganglion cell complex), except for pore verticality, which was not correlated with retinal nerve fiber layer.
The LC pores of patients with HTG appear to be more tortuous than the pores of patients with NG, and the pores of patients with NTG are shorter than those of patients with NG. Changes in pore parameters appear to be associated with the severity of glaucomatous optic neuropathy.
高压性青光眼（HTG）患者的筛板孔似乎比非青光眼（NG）患者的筛板孔更曲折。
通过对断层图像重建，比较 HTG、正常眼压性青光眼（NTG）和 NG 患者的 LC 孔微结构。
对 29 例患者的 52 只眼（18 只 NG、18 只 HTG 和 16 只 NTG）的光谱域光学相干断层扫描图像进行分析。使用分割软件追踪孔。比较三组之间的孔长度、扭曲度和垂直度这 3 个定量参数。进行相关分析以确定协变量对 3 个定量参数的影响。
HTG 组的孔扭曲度（1.419 ± 0.093）明显高于 NG 组（1.347 ± 0.034，P = 0.011），但与 NTG 组无差异（P = 0.251）。此外，NTG 组的孔明显较短（P = 0.005）。NG 和 NTG 组的孔扭曲度或垂直度无差异（P = 0.587 和 P = 0.120）。HTG 眼的孔垂直性和长度与 NG 眼（P = 0.049 和 P = 0.033）和 NTG 眼（P = 0.827 和 P = 0.968）无显著差异。除了孔垂直性与神经纤维层无相关性外，所有测量的定量参数均与年龄无关，但与青光眼严重程度（视野指数、平均偏差、视网膜神经纤维层和节细胞复合体）相关。
HTG 患者的 LC 孔似乎比 NG 患者的孔更曲折，NTG 患者的孔比 NG 患者的孔更短。孔参数的变化似乎与青光眼视神经病变的严重程度有关。
