Department of Chemistry, University of Botswana, Gaborone, Botswana.
Boitekanelo College, Gaborone, Botswana.
Nat Prod Res. 2024 Aug;38(15):2637-2643. doi: 10.1080/14786419.2023.2196076. Epub 2023 Mar 30.
Chemical investigation of the stem bark of Taub. led to the isolation of two new natural compounds named 3-hydroxy-2,5,2'-trimethoxybibenzyl () and 2'-hydroxy-2,3,5,6-tetramethoxybibenzyl (), the latter has been previously reported as a synthetic compound, together with twelve known compounds . The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. Known bibenzyls , bauhinoxepin J (), and isoflavones and , were reported from genus for the first time. The isolated compounds were evaluated for their antibacterial activities against and . The bioactivity evaluation revealed that bibenzyls and showed weak inhibitory activity with MIC values of 1000 µg/mL against and bauhinoxepin J () showed moderate inhibitory activity with MIC value of 63 µg/mL against .
对 Taub.的茎皮进行化学研究，分离得到两个新的天然化合物，分别命名为 3-羟基-2,5,2'-三甲氧基二苄基（）和 2'-羟基-2,3,5,6-四甲氧基二苄基（），后者以前曾报道为合成化合物，此外还分离得到了十二个已知化合物。通过 NMR 分析和质谱以及与文献中报道的数据进行比较，阐明了分离得到的化合物的化学结构。首次从该属中报道了已知的二苄基、bauhinoxepin J（）和异黄酮和。对分离得到的化合物进行了抗菌活性测试，评估其对 和 的抑制作用。生物活性评价表明，二苄基 和 对 和 的 MIC 值分别为 1000 µg/mL，表现出较弱的抑制活性，bauhinoxepin J（）对 的 MIC 值为 63 µg/mL，表现出中等抑制活性。
