Gibson Peter G, McDonald Vanessa M
Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, Australia
Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia.
Eur Respir J. 2024 Dec 5;64(6). doi: 10.1183/13993003.00861-2024. Print 2024 Dec.
People with asthma experience many different problems related to their illness. The number and type of problems differ between patients. This results in asthma being a complex and heterogeneous disorder which mandates a personalised approach to management. These features pose very significant challenges for the effective implementation of evidence-based management. "Treatable traits" is a model of care that has been specifically designed to address these issues. Traits are identified in the pulmonary, extrapulmonary (comorbidity) and behavioural/risk factor domains. Traits are clinically relevant, recognisable with validated trait identification markers and treatable using evidence-based therapies. The clinician and patient agree on a personalised management plan that addresses the relevant traits, and trials show superiority of this approach with significant improvements in asthma control and quality of life. A number of tools have now been developed to assist the clinician in the implementation of this approach. The success of the treatable traits model of care is now being realised in other disease areas.
哮喘患者会经历许多与疾病相关的不同问题。患者之间问题的数量和类型各不相同。这导致哮喘成为一种复杂的异质性疾病,需要个性化的管理方法。这些特征给有效实施循证管理带来了非常重大的挑战。“可治疗特征”是一种专门为解决这些问题而设计的护理模式。特征在肺部、肺外(合并症)和行为/风险因素领域中被识别。特征具有临床相关性,可通过经过验证的特征识别标志物识别,并可使用循证疗法进行治疗。临床医生和患者就针对相关特征的个性化管理计划达成一致,试验表明这种方法具有优越性,能显著改善哮喘控制和生活质量。现在已经开发了一些工具来帮助临床医生实施这种方法。可治疗特征护理模式的成功正在其他疾病领域得到体现。