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From Single-omics to Clinically Integrated Multi-omics: Towards Bio-Clinical AI.

作者信息

Carraro Silvia, Martinez Fernando D

机构信息

University of Padova , Department of Women's and Children's Health, Padova, Italy.

The University of Arizona Asthma & Airway Disease Research Center, Tucson, Arizona, United States;

出版信息

Am J Respir Crit Care Med. 2025 Mar 24;211(5):672-3. doi: 10.1164/rccm.202501-0231ED.

DOI:10.1164/rccm.202501-0231ED
PMID:40126440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12091009/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c25/12091009/8dd8454750c7/rccm.202501-0231EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c25/12091009/8dd8454750c7/rccm.202501-0231EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c25/12091009/8dd8454750c7/rccm.202501-0231EDf1.jpg

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本文引用的文献

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Exploring the Varied Clinical Presentation of Pediatric Asthma through the Metabolome.通过代谢组学探索儿童哮喘的多样临床表现
Am J Respir Crit Care Med. 2025 Feb 18. doi: 10.1164/rccm.202407-1382OC.
2
Integrating hot topics and implementation of treatable traits in asthma.整合哮喘的热点话题及可治疗特征的实施
Eur Respir J. 2024 Dec 5;64(6). doi: 10.1183/13993003.00861-2024. Print 2024 Dec.
3
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma.深度多组学分析揭示了构成学龄前喘息和哮喘基础的分子特征。
J Allergy Clin Immunol. 2025 Jan;155(1):94-106. doi: 10.1016/j.jaci.2024.08.017. Epub 2024 Aug 28.
4
Embedding AI in biology.将人工智能融入生物学。
Nat Methods. 2024 Aug;21(8):1365-1366. doi: 10.1038/s41592-024-02391-7.
5
Common Data Elements Repository.通用数据元素库。
Med Ref Serv Q. 2024 Apr-Jun;43(2):182-190. doi: 10.1080/02763869.2024.2323896. Epub 2024 May 9.
6
Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years?代谢组学在儿童哮喘中的应用：过去十年我们学到了什么？
Children (Basel). 2023 Aug 25;10(9):1452. doi: 10.3390/children10091452.
7
Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.代谢组学在肥胖相关儿童哮喘亚型分型中的应用：一项叙述性综述
Metabolites. 2023 Feb 23;13(3):328. doi: 10.3390/metabo13030328.
8
Treatable Traits in Airway Disease: From Theory to Practice.气道疾病可治疗的特征：从理论到实践。
J Allergy Clin Immunol Pract. 2023 Mar;11(3):713-723. doi: 10.1016/j.jaip.2023.01.011. Epub 2023 Feb 1.
9
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.精准干预严重和/或易恶化型（PrecISE）哮喘网络：网络组织、程序和干预概述。
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Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study.在 U-BIOPRED 研究中，严重哮喘的尿代谢组型证据表明，肉毒碱代谢减少与口服皮质类固醇治疗无关。
Eur Respir J. 2022 Jun 30;59(6). doi: 10.1183/13993003.01733-2021. Print 2022 Jun.