Service ORL Et Chirurgie Cervicofaciale, Centre Hospitalier de Valence, 179 Boulevard du Maréchal Juin, 26953, Valence, France.
Université de Bourgogne Franche Comté, Esplanade Erasme, 21000, Dijon, France.
Support Care Cancer. 2024 Sep 11;32(10):651. doi: 10.1007/s00520-024-08854-z.
Metallic taste (MT) is frequently observed during head and neck cancer treatments, but very little is known about its impact on nutritional status. The aim of this study was to explore the impact of MT on the quality of life and nutritional status in patients with head and neck cancer expressing MT.
Questionnaires on quality of life, MT, weight, and food intake were filled out by 44 patients with head and neck cancer before, during, and up to 1 year after their treatment. Patients were divided into two groups based on their reported experience of MT.
MT was commonly observed (n = 12, 27.2%), always during the treatment phase, and mostly linked with radiotherapy or radiochemotherapy. Reported MT intensity was moderate (n = 6, 40%) to high (n = 4, 26.7%). MT had a significant negative impact on quality of life linked to dysgeusia (p = 0.025). The negative impacts of MT on food intake and on weight were not significant, possibly due to a combination of sample size, dropouts, and duration of observation. Further research in this area could provide additional insights into how to better address the issue related to MT and enhance the quality of care provided to this patient population.
Metallic taste, experienced by 27.2% of the 44 patients with head and neck cancer, contributes to dysgeusia and results in a significant decline in quality of life associated with dysgeusia.
ClinicalTrials.gov trial registration number: NCT03558789.
在头颈部癌症治疗过程中经常会出现金属味（MT），但对于其对营养状况的影响知之甚少。本研究旨在探讨 MT 对头颈部癌症患者（表达 MT）生活质量和营养状况的影响。
44 例头颈部癌症患者在治疗前、治疗中和治疗后 1 年内填写了生活质量、MT、体重和食物摄入的问卷。根据患者报告的 MT 体验，将患者分为两组。
MT 很常见（n=12，27.2%），始终发生在治疗阶段，主要与放疗或放化疗有关。报告的 MT 强度为中度（n=6，40%）至高度（n=4，26.7%）。MT 对与味觉障碍相关的生活质量有显著的负面影响（p=0.025）。MT 对食物摄入和体重的负面影响不显著，可能是由于样本量、脱落和观察时间的综合作用。在这一领域的进一步研究可能会提供更多关于如何更好地解决与 MT 相关问题和提高对这一患者群体的护理质量的见解。
27.2%的 44 例头颈部癌症患者经历了金属味，这导致了味觉障碍，并导致与味觉障碍相关的生活质量显著下降。
ClinicalTrials.gov 临床试验注册号：NCT03558789。
