癌症患者化疗后口中有金属味。
Metallic taste in cancer patients treated with chemotherapy.
机构信息
Top Institute Food and Nutrition, Wageningen, The Netherlands; Neuroimaging Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Top Institute Food and Nutrition, Wageningen, The Netherlands; Neuroimaging Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
出版信息
Cancer Treat Rev. 2015 Feb;41(2):179-86. doi: 10.1016/j.ctrv.2014.11.006. Epub 2014 Dec 5.
BACKGROUND
Metallic taste is a taste alteration frequently reported by cancer patients treated with chemotherapy. Attention to this side effect of chemotherapy is limited. This review addresses the definition, assessment methods, prevalence, duration, etiology, and management strategies of metallic taste in chemotherapy treated cancer patients.
METHODS
Literature search for metallic taste and chemotherapy was performed in PubMed up to September 2014, resulting in 184 articles of which 13 articles fulfilled the inclusion criteria: English publications addressing metallic taste in cancer patients treated with FDA-approved chemotherapy. An additional search in Google Scholar, in related articles of both search engines, and subsequent in the reference lists, resulted in 13 additional articles included in this review. Cancer patient forums were visited to explore management strategies.
FINDINGS
Prevalence of metallic taste ranged from 9.7% to 78% among patients with various cancers, chemotherapy treatments, and treatment phases. No studies have been performed to investigate the influence of metallic taste on dietary intake, body weight, and quality of life. Several management strategies can be recommended for cancer patients: using plastic utensils, eating cold or frozen foods, adding strong herbs, spices, sweetener or acid to foods, eating sweet and sour foods, using 'miracle fruit' supplements, and rinsing with chelating agents.
INTERPRETATION
Although metallic taste is a frequent side effect of chemotherapy and a much discussed topic on cancer patient forums, literature regarding metallic taste among chemotherapy treated cancer patients is scarce. More awareness for this side effect can improve the support for these patients.
背景
金属味是癌症患者在接受化疗时常报告的一种味觉改变。对这种化疗副作用的关注有限。本综述探讨了化疗治疗癌症患者金属味的定义、评估方法、患病率、持续时间、病因和管理策略。
方法
在 PubMed 上对金属味和化疗进行了文献检索，截至 2014 年 9 月，共检索到 184 篇文章，其中 13 篇文章符合纳入标准：英文出版物涉及接受 FDA 批准的化疗的癌症患者的金属味。在 Google Scholar 上进行了额外的搜索，在两个搜索引擎的相关文章中，以及随后在参考文献列表中，又有 13 篇文章被纳入本综述。访问癌症患者论坛，以探讨管理策略。
结果
在接受各种癌症、化疗治疗和治疗阶段的患者中，金属味的患病率从 9.7%到 78%不等。尚未进行研究来调查金属味对饮食摄入、体重和生活质量的影响。可以为癌症患者推荐几种管理策略：使用塑料餐具、食用冷食或冷冻食品、在食物中添加强草药、香料、甜味剂或酸、食用酸甜食物、使用“奇迹果”补充剂，以及用螯合剂漱口。
解释
尽管金属味是化疗的常见副作用，也是癌症患者论坛上讨论较多的话题，但关于化疗治疗癌症患者金属味的文献却很少。更多地关注这种副作用可以更好地为这些患者提供支持。
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