奎宁过量导致死亡和失明。
Death and blindness due to overdose of quinine.
作者信息
Dyson E H, Proudfoot A T, Prescott L F, Heyworth R
出版信息
Br Med J (Clin Res Ed). 1985 Jul 6;291(6487):31-3. doi: 10.1136/bmj.291.6487.31.
Abstract
During 1953-83 there were 48 admissions to the regional poisoning treatment centre, Edinburgh, for overdose of quinine including 19 since 1978. Six patients were blind and one had ventricular tachycardia. Stellate ganglion block was performed without benefit in seven patients. No patient died, but three deaths from cardiotoxicity occurred in a further 71 patients reported to the Scottish Poisons Information Bureau. Plasma quinine concentration related to time from ingestion was found to be a useful predictor of visual toxicity.
摘要
1953年至1983年间，有48例因过量服用奎宁而入住爱丁堡地区中毒治疗中心，其中自1978年以来有19例。6例患者失明，1例出现室性心动过速。7例患者接受星状神经节阻滞治疗但无效。无患者死亡，但向苏格兰毒物信息局报告的另外71例患者中有3例死于心脏毒性。发现血浆奎宁浓度与摄入时间的关系是视觉毒性的有用预测指标。
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Acta Ophthalmol (Copenh). 1955;33(3):217-28. doi: 10.1111/j.1755-3768.1955.tb00059.x.
2
Fatalities and complications after attempts at stellate ganglion block.
Surgery. 1952 Oct;32(4):615-9.
3
Ocular quinine toxicity.
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4
Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.
Am J Ophthalmol. 1980 Mar;89(3):425-30. doi: 10.1016/0002-9394(80)90015-x.
5
Total reversible blindness following attempted stellate ganglion block.
Anesth Analg. 1981 Sep;60(9):689-90.
6
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Invest Ophthalmol Vis Sci. 1984 Apr;25(4):381-8.
8
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J Opt Soc Am. 1983 Dec;73(12):1701-8. doi: 10.1364/josa.73.001701.
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