The School of Public Health, Nanjing Medical University, Nanjing, China; The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, China.
The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, China.
Environ Pollut. 2024 Dec 1;362:124943. doi: 10.1016/j.envpol.2024.124943. Epub 2024 Sep 10.
Although the effects of traditional perfluorinated and polyfluorinated substances (PFASs) exposure have been extensively explored, research on novel PFASs remains limited, and there is a lack of data regarding their placental transfer and fetal impact. Herein, we aimed to examine maternal and fetal PFASs exposure levels, placental transfer efficiency (TTE), and the consequences of prenatal exposure on birth weight. The study included 214 mother-child pairs recruited in Wuxi birth cohort from 2019 to 2021. Twenty-three PFASs were quantified in maternal serum during the second trimester and umbilical serum during delivery. Median concentrations of ∑PFASs in maternal and cord sera were 9.34 and 6.88 ng/mL, respectively. The novel alternatives exhibited elevated levels of maternal and fetal exposure, such as perfluorovaleric acid (PFPeA, 2.00 ng/mL and 1.66 ng/mL, respectively) and perfluorohexane sulfonate (PFHxS, 1.77 and 1.14 ng/mL, respectively). With increasing carbon chain length, the TTE of perfluorocarbonic acid (PFCAs) displayed a pattern of initially decreasing before subsequently increasing, with novel alternatives exhibiting a relatively high TTE. Multiple linear regression showed that exposure to perfluorobutane sulfonate (PFBS) and PFPeA in cord serum positively correlated with the birth weight of female infants (β = 231.04 g, 95% confidence interval [CI]: 21.73-440.36; β = 121.26 g, 95% CI: 29.51-213.00). No nonlinear relationship was observed between cord serum PFASs and birth weight. The weighted quantile sum (WQS) regression analysis has reaffirmed that PFPeA and PFBS were predominant contributors to the positive correlation observed between the mixture of PFASs and birth weight. Our findings suggest that novel PFASs may exhibit a heightened susceptibility for transplacental transfer and that exposure to PFBS and PFPeA during pregnancy could be linked to increased birth weight.
尽管传统的全氟和多氟化合物 (PFAS) 暴露的影响已经得到了广泛的研究，但对新型 PFAS 的研究仍然有限，而且关于它们在胎盘内的转移和对胎儿的影响的数据也很缺乏。在这里，我们旨在检查母体和胎儿 PFAS 暴露水平、胎盘转移效率 (TTE) 以及产前暴露对出生体重的影响。这项研究包括了 2019 年至 2021 年期间在无锡出生队列中招募的 214 对母婴。在妊娠中期测量了母体血清中的 23 种 PFAS，分娩时测量了脐血清中的 23 种 PFAS。母体和脐带血清中∑PFASs 的中位数浓度分别为 9.34 和 6.88ng/mL。新型替代品表现出较高的母体和胎儿暴露水平，例如全氟戊酸 (PFPeA，分别为 2.00ng/mL 和 1.66ng/mL) 和全氟己烷磺酸 (PFHxS，分别为 1.77ng/mL 和 1.14ng/mL)。随着碳链长度的增加，全氟羧酸 (PFCAs) 的 TTE 呈现出先降低后升高的模式，新型替代品表现出相对较高的 TTE。多元线性回归显示，脐带血清中 PFBS 和 PFPeA 的暴露与女婴的出生体重呈正相关 (β=231.04g，95%置信区间 [CI]：21.73-440.36；β=121.26g，95% CI：29.51-213.00)。脐带血清 PFASs 与出生体重之间未观察到非线性关系。加权分位数总和 (WQS) 回归分析再次证实，PFPeA 和 PFBS 是 PFAS 混合物与出生体重之间正相关的主要贡献者。我们的研究结果表明，新型 PFAS 可能表现出更高的胎盘转移易感性，怀孕期间 PFBS 和 PFPeA 的暴露可能与出生体重增加有关。
