Zhao Yinan, Nie Fan, Liu Wenhui, He Wenrui, Guo Yuanqiang
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Int J Biol Macromol. 2024 Sep 10;280(Pt 1):135347. doi: 10.1016/j.ijbiomac.2024.135347.
With the continuous advancement of nanotechnology, the application of gold nanorods (AuNRs) functionalized with polysaccharides in the realm of cancer photothermal therapy is garnering increasing attention. To harness photothermal therapy for cancer treatment, FLP-MPBA-AuNRs were successfully synthesized in this study for the first time, utilizing Poria cocos polysaccharides (FLP), mercaptophenylboronic acid (MPBA), and gold nanorods (AuNRs). FLP-MPBA-AuNRs are a nanomaterial characterized by a unique rod-shaped structure, featuring a long diameter of 29.3 nm and a short diameter of 6.5 nm, which conferred exceptional photothermal stability and remarkable photothermal conversion efficiency. Under near-infrared light irradiation, FLP-MPBA-AuNRs elicited significant photothermal effects, effectively curtailing the proliferation of various cancer cells. Additionally, FLP-MPBA-AuNRs impeded cancer progression by inducing cell apoptosis and releasing reactive oxygen species (ROS). Furthermore, FLP-MPBA-AuNRs suppressed the metastasis and growth of cancer cells in zebrafish models. In summary, FLP-MPBA-AuNRs showcased immense potential in cancer therapy by inhibiting tumor cell growth through photothermal and photodynamic mechanisms.
随着纳米技术的不断进步，多糖功能化的金纳米棒（AuNRs）在癌症光热治疗领域的应用受到越来越多的关注。为了利用光热疗法治疗癌症，本研究首次成功合成了茯苓多糖（FLP）、巯基苯硼酸（MPBA）和金纳米棒（AuNRs）组成的FLP-MPBA-AuNRs。FLP-MPBA-AuNRs是一种具有独特棒状结构的纳米材料，长径为29.3nm，短径为6.5nm，具有优异的光热稳定性和显著的光热转换效率。在近红外光照射下，FLP-MPBA-AuNRs产生显著的光热效应，有效抑制各种癌细胞的增殖。此外，FLP-MPBA-AuNRs通过诱导细胞凋亡和释放活性氧（ROS）来阻碍癌症进展。此外，FLP-MPBA-AuNRs在斑马鱼模型中抑制了癌细胞的转移和生长。总之，FLP-MPBA-AuNRs通过光热和光动力机制抑制肿瘤细胞生长，在癌症治疗中展现出巨大潜力。
