发明新型蛋白质折叠。
Inventing Novel Protein Folds.
机构信息
Laboratory for Protein Design, Institute for Protein Research (IPR), Osaka University, Suita, Osaka 565-0871, Japan; Protein Design Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan.
Laboratory for Protein Design, Institute for Protein Research (IPR), Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
J Mol Biol. 2024 Nov 1;436(21):168791. doi: 10.1016/j.jmb.2024.168791. Epub 2024 Sep 12.
The vastness of unexplored protein fold universe remains a significant question. Through systematic de novo design of proteins with novel αβ-folds, we demonstrated that nature has only explored a tiny portion of the possible folds. Numerous possible protein folds are still untouched by nature. This review outlines this study and discusses the prospects for design of functional proteins with novel folds.
未探索的蛋白质折叠宇宙的广阔仍然是一个重要的问题。通过对具有新型 αβ-折叠的蛋白质进行系统的从头设计，我们证明了自然界只探索了一小部分可能的折叠。还有许多可能的蛋白质折叠尚未被自然界触及。本文概述了这项研究，并讨论了设计具有新型折叠的功能蛋白质的前景。
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