Fourth Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08, Prague, Czech Republic.
Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Na Bojišti 3, 121 08, Prague, Czech Republic.
Nutr Diabetes. 2024 Sep 11;14(1):73. doi: 10.1038/s41387-024-00332-z.
The role of fatty acids (FA) in the pathogenesis of insulin resistance and hyperlipidemia is a subject of intensive research. Several recent works have suggested cis-vaccenic acid (cVA) in plasma lipid compartments, especially in plasma phospholipids (PL) or erythrocyte membranes, could be associated with markers of insulin sensitivity and cardiovascular health. Nevertheless, not all the results of research work testify to these beneficial effects of cVA. Therefore, we decided to investigate the relations of proportion of cVA in plasma PL to markers of insulin resistance in hyperlipidemic men.
In 231 men (median age 50) with newly diagnosed hyperlipidemia, we analyzed basic clinical parameters together with FA composition of plasma PL and stratified them according to the content of cVA into upper quartile (Q4) and lower quartile (Q1) groups. We examined also small control group of 50 healthy men.
The individuals in Q4 differed from Q1 by lower plasma insulin (p < 0.05), HOMA-IR values (p < 0.01), and apolipoprotein B concentrations (p < 0.001), but by the higher total level of nonesterified FA (p < 0.01). Both groups had similar age, anthropometrical, and other lipid parameters. In plasma PL, the Q4 group had lower content of the sum of n-6 polyunsaturated FA, due to decrease of γ-linolenic and dihomo-γ-linolenic acids, whereas the content of monounsaturated FA (mainly oleic and palmitoleic) was in Q4 higher.
Our results support hypothesis that plasma PL cVA could be associated with insulin sensitivity in men with hyperlipidemia.
脂肪酸（FA）在胰岛素抵抗和血脂异常发病机制中的作用是一个研究热点。最近的几项研究表明，顺式-亚麻酸（cVA）在血浆脂质（PL）或红细胞膜等血浆脂质（PL）中的含量可能与胰岛素敏感性和心血管健康的标志物有关。然而，并非所有研究工作的结果都证明了 cVA 的这些有益作用。因此，我们决定研究高血脂男性中 cVA 在血浆 PL 中的比例与胰岛素抵抗标志物之间的关系。
在 231 名新诊断为高血脂的男性（中位年龄 50 岁）中，我们分析了基本的临床参数以及 PL 中的 FA 组成，并根据 cVA 的含量将其分为上四分位数（Q4）和下四分位数（Q1）组。我们还检查了 50 名健康男性的小对照组。
Q4 组与 Q1 组相比，血浆胰岛素（p<0.05）、HOMA-IR 值（p<0.01）和载脂蛋白 B 浓度（p<0.001）较低，但非酯化 FA 总量（p<0.01）较高。两组的年龄、人体测量学和其他脂质参数相似。在 PL 中，Q4 组由于 γ-亚麻酸和二同型-γ-亚麻酸的减少，n-6 多不饱和 FA 的总和含量较低，而单不饱和 FA（主要是油酸和棕榈油酸）的含量在 Q4 较高。
我们的结果支持这样的假设，即高血脂男性血浆 PL 中的 cVA 可能与胰岛素敏感性有关。
