Department of Cardiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China.
Department of Cardiology, The First People's Hospital of Jinzhong, Jinzhong, 030602, China.
Lipids Health Dis. 2024 Sep 11;23(1):292. doi: 10.1186/s12944-024-02274-y.
The purpose of this study was to analyze the dynamic trends of ischemic heart disease (IHD) mortality attributable to high low-density lipoprotein cholesterol (LDL-C).
Data on IHD mortality attributable to high LDL-C from 1990 to 2021 were extracted from the global disease burden database. Joinpoint software was used to estimate the average annual percentage change (AAPC) in the age-standardized mortality rate (ASMR). An age‒period‒cohort model was used to analyze the impacts of age, period, and cohort on these changes. The Bayesian framework was used to predict IHD mortality attributable to high LDL-C from 2022 to 2040.
The overall ASMR of IHD attributable to high LDL-C decreased from 50. 479 per 100,000 people in 1990 to 32.286 per 100,000 people in 2021, and ASMR of IHD attributable to high LDL-C was higher in males than in females. The longitudinal age curves of the overall IHD mortality attributable to high LDL-C showed a monotonic upward trend, especially after 65 years of age. The period and cohort effect relative risk (RR) values of overall IHD mortality attributable to high LDL-C showed a downward trend. The overall ASMR of IHD attributable to high LDL-C is predicted to show a downward trend, and male IHD mortality attributable to high LDL-C is expected to be higher than that of females.
This study revealed a sustained decrease in IHD mortality attributable to high LDL-C over three decades, with a continued decline expected. Despite this, gender disparities persist, with males experiencing higher mortality rates and elderly individuals remaining a vulnerable group.
本研究旨在分析归因于高低密度脂蛋白胆固醇（LDL-C）的缺血性心脏病（IHD）死亡率的动态趋势。
从全球疾病负担数据库中提取了 1990 年至 2021 年归因于高 LDL-C 的 IHD 死亡率数据。使用 Joinpoint 软件估计年龄标准化死亡率（ASMR）的平均年变化百分比（AAPC）。采用年龄-时期-队列模型分析年龄、时期和队列对这些变化的影响。采用贝叶斯框架预测 2022 年至 2040 年归因于高 LDL-C 的 IHD 死亡率。
归因于高 LDL-C 的 IHD 的总体 ASMR 从 1990 年的每 10 万人 50.479 人下降到 2021 年的每 10 万人 32.286 人，且归因于高 LDL-C 的 IHD 在男性中高于女性。归因于高 LDL-C 的总体 IHD 死亡率的纵向年龄曲线呈单调上升趋势，尤其是在 65 岁以上。归因于高 LDL-C 的总体 IHD 死亡率的时期和队列效应相对风险（RR）值呈下降趋势。归因于高 LDL-C 的总体 IHD 的 ASMR 预计呈下降趋势，且男性归因于高 LDL-C 的 IHD 死亡率预计高于女性。
本研究揭示了 30 多年来归因于高 LDL-C 的 IHD 死亡率持续下降，预计还会继续下降。尽管如此，性别差异仍然存在，男性死亡率较高，老年人仍是弱势群体。
