Ioachimescu Octavian C, Shaker Reza
Medical College of Wisconsin, Milwaukee, WI, USA.
J Investig Med. 2025 Jan;73(1):3-26. doi: 10.1177/10815589241283515. Epub 2024 Oct 29.
Translational research moves scientific discoveries and innovations across the development spectrum for a particular target or disease, trying to bridge in a multidisciplinary fashion the gap between laboratory scientific discoveries and practical, real-world applications in medicine and in healthcare. Translational research aims to move research findings across settings, specific languages, methodologies, and study designs, from laboratory to clinical practice and ultimately into community- and population-level health benefits. In contrast, translational science is a distinct field, which evolved over time toward a systematic study and practice of operationalizing the translation of content from one language, ecosystem, environment, contextual landscape, culture, discipline, area, or domain into another. It involves systematic and transdisciplinary integration of knowledge from basic science, clinical research and population science to improve human health, better longevity, and to ensure disease- and disability-free lives. Translational science often uses knowledge, operational frameworks, and specific capabilities borrowed from other specialties, disciplines, and fields such as operations management, implementation and dissemination science, quality improvement and management, project management, public health, intervention science, change management and leadership, decision science, design thinking, functional design, data science, communication and marketing science, etc. The main goal of this article is to open a series of thematic reviews in this journal, introducing the reader to the main definitions, contingencies, touchpoints, and overlapping areas between translational science and these related specialties, disciplines, and fields of study. Transdisciplinary capabilities borrowing from these related specialties can create a robust translational science machinery for health systems, research organizations, and innovation hubs.
转化研究将科学发现和创新应用于特定目标或疾病的整个发展过程，试图以多学科方式弥合实验室科学发现与医学及医疗保健领域实际应用之间的差距。转化研究旨在跨越不同环境、特定语言、方法和研究设计，将研究成果从实验室转化到临床实践，并最终实现社区和人群层面的健康效益。相比之下，转化科学是一个独特的领域，它随着时间的推移逐渐发展成为对将内容从一种语言、生态系统、环境、背景、文化、学科、领域或范畴转化到另一种的过程进行系统研究和实践。它涉及基础科学、临床研究和人群科学知识的系统和跨学科整合，以改善人类健康、延长寿命并确保无疾病和残疾的生活。转化科学经常借鉴其他专业、学科和领域（如运营管理、实施与传播科学、质量改进与管理、项目管理、公共卫生、干预科学、变革管理与领导力决策科学、设计思维、功能设计、数据科学、传播与营销科学等）的知识、运营框架和特定能力。本文的主要目的是在本期刊开启一系列专题综述，向读者介绍转化科学与这些相关专业、学科和研究领域之间的主要定义、偶然因素、接触点和重叠领域。借鉴这些相关专业的跨学科能力可为卫生系统、研究机构和创新中心打造强大的转化科学机制。
