Zhang Tianqi, Wang Yunshen, Feng Xingdong, Zuo Yizhou, Yu Hannong, Bao Hong, Jiang Fan, Jiang Shan
Hangzhou Institute of Technology, Xidian University, Hangzhou 311200, China.
Department of Pneumology, Tianjin Children's Hospital, Children's Hospital, Tianjin University, Tianjin 300204, China.
iScience. 2024 Aug 12;27(9):110707. doi: 10.1016/j.isci.2024.110707. eCollection 2024 Sep 20.
Cardiovascular diseases (CVDs) pose a significant global health threat, responsible for a considerable portion of worldwide mortality. Flexible electronics enable continuous, noninvasive, real-time, and portable monitoring, providing an ideal platform for personalized healthcare. Nevertheless, challenges persist in sustaining stable adherence across diverse and intricate skin environments, hindering further advancement toward clinical applications. Strategies such as structural design and chemical modification can significantly enhance the environmental adaptability and monitoring performance of flexible electronics. This review delineates processing techniques, including structural design and chemical modification, to mitigate signal interference from sebaceous skin, motion artifacts from the skin in motion, and infection risks from fragile skin, thereby enabling the accurate monitoring of key cardiovascular indicators in complex physiological environments. Moreover, it delves into the potential for the strategic development and improvement of flexible electronics to ensure their alignment with complex physiological environment requirements, facilitating their transition to clinical applications.
心血管疾病（CVDs）对全球健康构成重大威胁，在全球死亡率中占相当大的比例。柔性电子器件能够实现连续、无创、实时和便携式监测，为个性化医疗提供了理想平台。然而，在各种复杂的皮肤环境中持续保持稳定的附着性仍存在挑战，阻碍了其向临床应用的进一步发展。诸如结构设计和化学修饰等策略可以显著提高柔性电子器件的环境适应性和监测性能。本综述阐述了包括结构设计和化学修饰在内的处理技术，以减轻来自皮脂腺皮肤的信号干扰、运动皮肤的运动伪影以及脆弱皮肤的感染风险，从而能够在复杂生理环境中准确监测关键心血管指标。此外，还深入探讨了柔性电子器件战略发展和改进的潜力，以确保其符合复杂生理环境要求，促进其向临床应用的转变。
