Zhang Tianqi, Liu Ning, Xu Jing, Liu Zeye, Zhou Yunlei, Yang Yicheng, Li Shoujun, Huang Yuan, Jiang Shan
Hangzhou Institute of Technology, Xidian University, Hangzhou 311200, China.
Department of Gastrointestinal Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China.
Innovation (Camb). 2023 Jul 24;4(5):100485. doi: 10.1016/j.xinn.2023.100485. eCollection 2023 Sep 11.
Cardiovascular diseases (CVDs) are one of the most urgent threats to humans worldwide, which are responsible for almost one-third of global mortality. Over the last decade, research on flexible electronics for monitoring and treatment of CVDs has attracted tremendous attention. In contrast to conventional medical instruments in hospitals that are usually bulky, hard to move, monofunctional, and time-consuming, flexible electronics are capable of continuous, noninvasive, real-time, and portable monitoring. Notable progress has been made in this emerging field, and thus a number of significant achievements and concomitant research prospects deserve attention for practical implementation. Here, we comprehensively review the latest progress of flexible electronics for CVDs, focusing on new functions provided by flexible electronics. First, the characteristics of CVDs and flexible electronics and the foundation of their combination are briefly reviewed. Then, four representative applications of flexible electronics for CVDs are elaborated: blood pressure (BP) monitoring, electrocardiogram (ECG) monitoring, echocardiogram monitoring, and direct epicardium monitoring. Their operational principles, progress, merits and demerits, and future efforts are discussed. Finally, the remaining challenges and opportunities for flexible electronics for cardiovascular healthcare are outlined.
心血管疾病（CVDs）是全球人类面临的最紧迫威胁之一，几乎占全球死亡率的三分之一。在过去十年中，用于监测和治疗心血管疾病的柔性电子学研究引起了极大关注。与医院中通常体积庞大、难以移动、功能单一且耗时的传统医疗仪器不同，柔性电子学能够进行连续、无创、实时和便携式监测。在这个新兴领域已经取得了显著进展，因此，一些重大成就以及随之而来的研究前景值得关注以便实际应用。在此，我们全面回顾了用于心血管疾病的柔性电子学的最新进展，重点关注柔性电子学提供的新功能。首先，简要回顾了心血管疾病和柔性电子学的特点以及它们结合的基础。然后，详细阐述了柔性电子学在心血管疾病方面的四个代表性应用：血压（BP）监测、心电图（ECG）监测、超声心动图监测和直接心外膜监测。讨论了它们的工作原理、进展、优缺点以及未来的努力方向。最后，概述了用于心血管医疗保健的柔性电子学所面临的剩余挑战和机遇。
