Useckaite Zivile
Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Australia.
Obstet Med. 2024 Sep;17(3):179-183. doi: 10.1177/1753495X241264325. Epub 2024 Jul 25.
Extracellular vesicles (EVs) are small, nonreplicating, lipid-encapsulated nanoparticles that carry protein and nucleic acid cargo derived from their tissue of origin. Due to their capacity to provide comparable insights to solid organ biopsy through a minimally invasive collection procedure, EVs provide an attractive biomarker source. This review will provide an insight, how EVs in circulation may provide a novel way to assess cholestasis and will address the possibility of getting a better understanding of the mechanisms of cholestasis of pregnancy through the use of serial hepatic-specific EVs as a window.
细胞外囊泡（EVs）是微小的、非复制性的、脂质包裹的纳米颗粒，携带源自其起源组织的蛋白质和核酸货物。由于它们能够通过微创采集程序提供与实体器官活检相当的见解，EVs提供了一种有吸引力的生物标志物来源。本综述将深入探讨循环中的EVs如何提供一种评估胆汁淤积的新方法，并将探讨通过使用一系列肝脏特异性EVs作为窗口更好地理解妊娠期胆汁淤积机制的可能性。
