Vanderveen E E, Grekin R C, Swanson N A, Kragballe K
Arch Dermatol. 1986 Apr;122(4):407-12. doi: 10.1001/archderm.122.4.407.
There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF2 alpha formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF2 alpha) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern.
有证据表明类花生酸在某些肿瘤的生长中起作用。在本研究中，从皮肤的基底细胞癌（BCC）和鳞状细胞癌（SCC）中收集组织样本。BCC和SCC中的前列腺素E2和F2α（PGE2和PGF2α）均比正常表皮中含量更多。用花生四烯酸对肿瘤样本进行体外孵育也会导致PGE2和PGF2α的形成。在体内以及体外孵育后，组织学上呈现侵袭性生长模式的基底细胞癌所含前列腺素水平高于非侵袭性生长模式的基底细胞癌。在体内，脂氧合酶产物（12-和15-羟基二十碳四烯酸）的含量低于环氧化酶产物（PGE2和PGF2α）。与正常表皮相比，SCC，尤其是BCC在与花生四烯酸进行体外孵育时产生的12-羟基二十碳四烯酸较少。脂氧合酶产物的水平与肿瘤生长模式无关。这些结果表明，BCC中前列腺素水平过高可能与侵袭性生长模式有关。
