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Valproate-Autism Labyrinth.丙戊酸盐-自闭症迷宫。
Psychopharmacol Bull. 2024 Aug 19;54(4):131-133.
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Intravenous valproate for rapid stabilization of agitation in neuropsychiatric disorders.静脉注射丙戊酸盐用于快速稳定神经精神疾病中的激越症状。
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Sci Rep. 2021 Dec 6;11(1):23471. doi: 10.1038/s41598-021-02994-6.
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A male with fetal valproate syndrome and autism.一名患有胎儿丙戊酸综合征和自闭症的男性。
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Valproate in pregnancy linked to autism in children.孕期使用丙戊酸盐与儿童自闭症有关。
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Type of Prenatal Antiseizure Drug Matters for Children's Autism Risk.产前抗癫痫药物类型与儿童自闭症风险相关
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[A girl with foetal valproate syndrome and autism spectrum disorder].[一名患有胎儿丙戊酸盐综合征和自闭症谱系障碍的女孩]
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本文引用的文献

1
Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review.重新审视妊娠期丙戊酸暴露:对人和动物胚胎和胎儿产生神经行为、生化和分子改变的叙述性综述。
Int J Mol Sci. 2023 Dec 27;25(1):390. doi: 10.3390/ijms25010390.
2
Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder.30 年丙戊酸:自闭症谱系障碍的当前研究模型。
Curr Neuropharmacol. 2024;22(2):260-289. doi: 10.2174/1570159X22666231003121513.
3
Benzodiazepines in autism spectrum disorder-苯二氮䓬类药物与自闭症谱系障碍
CNS Spectr. 2022 Oct;27(5):552. doi: 10.1017/S1092852921000481. Epub 2021 May 3.
4
Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.母体叶酸补充可预防产前暴露于丙戊酸所致大鼠自闭症行为。
Food Funct. 2021 May 21;12(10):4544-4555. doi: 10.1039/d0fo02926b. Epub 2021 Apr 27.
5
Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment.丙戊酸诱导自闭症神经毒性事件的新机制及其对药物治疗的影响。
Biomed Pharmacother. 2021 May;137:111322. doi: 10.1016/j.biopha.2021.111322. Epub 2021 Feb 16.
6
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.抗癫痫药物在孕期的使用与儿童孤独症谱系障碍和注意缺陷多动障碍的风险
Neurology. 2020 Dec 15;95(24):e3232-e3240. doi: 10.1212/WNL.0000000000010993. Epub 2020 Oct 28.
7
Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Area.孕期暴露于丙戊酸钠会破坏中脑-间脑多巴胺能束的成束,导致腹侧被盖区多巴胺能输出选择性减少。
Front Neuroanat. 2020 Jun 5;14:29. doi: 10.3389/fnana.2020.00029. eCollection 2020.
8
Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero.妊娠期间补充叶酸与暴露于抗癫痫药物的儿童自闭症风险的关联。
JAMA Neurol. 2018 Feb 1;75(2):160-168. doi: 10.1001/jamaneurol.2017.3897.
9
Rett Syndrome-Current Status and Future Directions.雷特综合征——现状与未来方向
Pediatr Neurol. 2017 May;70:e5-e6. doi: 10.1016/j.pediatrneurol.2017.01.022. Epub 2017 Feb 4.
10
Successful Use of Sertindole for Severe Behavioral Dyscontrol in a Pediatric Case of Syndromic Autism Spectrum Disorder.在一例患有综合征性自闭症谱系障碍的儿科病例中,成功使用舍吲哚治疗严重行为失控
J Child Adolesc Psychopharmacol. 2017 Jun;27(5):471-472. doi: 10.1089/cap.2016.0182. Epub 2017 Mar 15.

丙戊酸盐-自闭症迷宫。

Valproate-Autism Labyrinth.

机构信息

Naguy, MBBch, MSc, MRCPsych (UK), Al-Manara CAP Centre, Kuwait Centre for Mental Health (KCMH), Jamal Abdul-Nassir St, Shuwaikh, State of Kuwait.

Alqabandi, PhD, Department of Nuclear Medicine, College of Medicine, Kuwait University, Kuwait.

出版信息

Psychopharmacol Bull. 2024 Aug 19;54(4):131-133.

PMID:39263199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11385261/
Abstract

Valproate and Autism complexity is manifold. From an established environmental risk factor for autism, to a translational animal model, valproate's composite mode of action might unfold to address core autistic domains transcending mere aggressive behavioural control.

摘要

丙戊酸盐与自闭症的复杂性是多方面的。从自闭症的既定环境风险因素,到转化动物模型,丙戊酸盐的复合作用模式可能会展开,以解决超越单纯攻击性行为控制的核心自闭症领域。