丙戊酸盐-自闭症迷宫。
Valproate-Autism Labyrinth.
机构信息
Naguy, MBBch, MSc, MRCPsych (UK), Al-Manara CAP Centre, Kuwait Centre for Mental Health (KCMH), Jamal Abdul-Nassir St, Shuwaikh, State of Kuwait.
Alqabandi, PhD, Department of Nuclear Medicine, College of Medicine, Kuwait University, Kuwait.
出版信息
Psychopharmacol Bull. 2024 Aug 19;54(4):131-133.
Abstract
Valproate and Autism complexity is manifold. From an established environmental risk factor for autism, to a translational animal model, valproate's composite mode of action might unfold to address core autistic domains transcending mere aggressive behavioural control.
摘要
丙戊酸盐与自闭症的复杂性是多方面的。从自闭症的既定环境风险因素，到转化动物模型，丙戊酸盐的复合作用模式可能会展开，以解决超越单纯攻击性行为控制的核心自闭症领域。
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本文引用的文献
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Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review.重新审视妊娠期丙戊酸暴露：对人和动物胚胎和胎儿产生神经行为、生化和分子改变的叙述性综述。
Int J Mol Sci. 2023 Dec 27;25(1):390. doi: 10.3390/ijms25010390.
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Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder.30 年丙戊酸：自闭症谱系障碍的当前研究模型。
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Benzodiazepines in autism spectrum disorder-苯二氮䓬类药物与自闭症谱系障碍
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Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.母体叶酸补充可预防产前暴露于丙戊酸所致大鼠自闭症行为。
Food Funct. 2021 May 21;12(10):4544-4555. doi: 10.1039/d0fo02926b. Epub 2021 Apr 27.
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Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment.丙戊酸诱导自闭症神经毒性事件的新机制及其对药物治疗的影响。
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