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从单纯睾丸畸胎瘤到原始神经外胚层肿瘤：一名年轻成人睾丸畸胎瘤恶变伴广泛转移的成功治疗

From pure testicular Teratoma to primitive neuroectodermal tumor: Successful management of Teratoma malignant transformation with widespread metastases in a young adult.

作者信息

Masoumi Navid, Amani-Beni Ali, Ataei Elnaz, Gharib Atoosa, Khorram Amir Alinejad

机构信息

Department of Urology, Shahid Modarress Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinical Development Center of Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Urol Case Rep. 2024 Aug 22;56:102830. doi: 10.1016/j.eucr.2024.102830. eCollection 2024 Sep.

DOI:10.1016/j.eucr.2024.102830
PMID:39263219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11388759/
Abstract

Midline retroperitoneal masses in young males often present a diagnostic challenge, with metastases from testicular origins being a primary consideration. Beyond the initial pathology of testicular cancer, these masses can undergo transformation, including the development of teratomas. This report describes an unusual case of a calcified retroperitoneal mass originating from a testicular pure teratoma that underwent a rare transformation into a Primitive Neuroectodermal Tumor (PNET), comprising approximately 85 % of the tumor volume. The patient's successful treatment involved a comprehensive approach combining surgical resection and chemotherapy.

摘要

年轻男性的腹膜后中线肿块常常带来诊断挑战，睾丸来源的转移瘤是主要考虑因素。除了睾丸癌的初始病理情况外，这些肿块还可能发生转变，包括畸胎瘤的形成。本报告描述了一例罕见病例，一名睾丸纯畸胎瘤起源的钙化腹膜后肿块发生了罕见转变，转变为原始神经外胚层肿瘤（PNET），该肿瘤约占肿块体积的85%。患者的成功治疗采用了手术切除和化疗相结合的综合方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/17b15a07329f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/7b9b97fa8816/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/b3f454f3b282/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/17b15a07329f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/7b9b97fa8816/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/b3f454f3b282/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ad/11388759/17b15a07329f/gr3.jpg

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1
From pure testicular Teratoma to primitive neuroectodermal tumor: Successful management of Teratoma malignant transformation with widespread metastases in a young adult.从单纯睾丸畸胎瘤到原始神经外胚层肿瘤：一名年轻成人睾丸畸胎瘤恶变伴广泛转移的成功治疗
Urol Case Rep. 2024 Aug 22;56:102830. doi: 10.1016/j.eucr.2024.102830. eCollection 2024 Sep.
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本文引用的文献

1
Transformed Testicular Teratoma to Embryonic-Type Neuroectodermal Tumor With Metastasis to Mediastinum.转化型睾丸生殖细胞瘤伴纵隔转移至胚胎型神经外胚层肿瘤。
J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231218145. doi: 10.1177/23247096231218145.
2
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.2022 年世界卫生组织泌尿系统和男性生殖器官肿瘤分类 - 第 A 部分：肾脏、阴茎和睾丸肿瘤。
Eur Urol. 2022 Nov;82(5):458-468. doi: 10.1016/j.eururo.2022.06.016. Epub 2022 Jul 16.
3
Metastatic Mature Teratoma and Growing Teratoma Syndrome in Patients with Testicular Non-Seminomatous Germ Cell Tumors.
睾丸非精原细胞瘤患者的转移性成熟畸胎瘤和生长性畸胎瘤综合征。
Korean J Radiol. 2021 Oct;22(10):1650-1657. doi: 10.3348/kjr.2020.1391. Epub 2021 Jul 26.
4
Primary intramedullary primitive neuroectodermal tumor: A case report and review of the literature.原发性髓内原始神经外胚层肿瘤：一例报告并文献复习
Medicine (Baltimore). 2017 Dec;96(49):e9001. doi: 10.1097/MD.0000000000009001.
5
A case series of transformation of teratoma to primitive neuroectodermal tumor: evolving management of a rare malignancy.畸胎瘤转化为原始神经外胚层肿瘤的病例系列：一种罕见恶性肿瘤的治疗进展
Rare Tumors. 2014 Mar 18;6(1):5268. doi: 10.4081/rt.2014.5268. eCollection 2014 Jan 23.
6
Metastatic malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): results with PNET-based chemotherapy.畸胎瘤向原始神经外胚层肿瘤（PNET）的转移性恶性转化：基于PNET的化疗结果。
Am J Clin Oncol. 2015 Aug;38(4):364-6. doi: 10.1097/COC.0b013e31829d1ed7.
7
Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor.转化型畸胎瘤向原始神经外胚层肿瘤患者的预后分析。
Ann Oncol. 2010 Sep;21(9):1846-1850. doi: 10.1093/annonc/mdq045. Epub 2010 Mar 15.