Bäckström T, Smith S, Lothian H, Baird D T
Clin Endocrinol (Oxf). 1985 Jun;22(6):723-32. doi: 10.1111/j.1365-2265.1985.tb00162.x.
In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid-luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterectomy for menstrual problems. In the luteal phase, before surgery, the concentration of progesterone and FSH was lower, while that of oestradiol was slightly higher, in women with PMS. Following enucleation of the corpus luteum, follicular development and ovulation recommenced more slowly in women with PMS compared to controls (time to ovulation: 21 (range 18-24, vs 19(14-20) d, P less than 0.01). During the follicular phase there was no difference between the two groups in the concentration of oestradiol. The rise in concentration of FSH following enucleation was delayed in patients with PMS, and the serum FSH concentration was significantly lower during the late follicular phase of the cycle, but not during the mid follicular phase. The results suggest that these women with PMS have a more sensitive 'feed-back' than the controls, resulting in a lower preovulatory FSH level even though the oestradiol levels were not different. The results also suggest that the abnormalities described during the preoperative luteal phase are associated with the delay in the initial FSH rise.
为了获取有关经前综合征（PMS）病因的更多信息，对7例PMS患者在月经周期黄体中期摘除黄体后的内分泌变化进行了研究，并将结果与7例因月经问题接受子宫切除术的对照患者的详细情况进行了比较。在黄体期，手术前，PMS女性的孕酮和促卵泡激素（FSH）浓度较低，而雌二醇浓度略高。与对照组相比，PMS女性摘除黄体后卵泡发育和排卵重新开始的速度更慢（排卵时间：21天（范围18 - 24天），对照组为19天（14 - 20天），P < 0.01）。在卵泡期，两组之间雌二醇浓度没有差异。PMS患者摘除黄体后FSH浓度的上升延迟，并且在月经周期卵泡晚期血清FSH浓度显著较低，但在卵泡中期并非如此。结果表明，这些PMS女性比对照组有更敏感的“反馈”，即使雌二醇水平没有差异，也导致排卵前FSH水平较低。结果还表明，术前黄体期描述的异常与初始FSH上升延迟有关。
