Wang Tianran, Toriumi Kazuya, Suzuki Kazuhiro, Miyashita Mitsuhiro, Ozawa Azuna, Masada Mayuko, Itokawa Masanari, Arai Makoto
Schizophrenia Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Neuropsychopharmacol Rep. 2024 Dec;44(4):728-736. doi: 10.1002/npr2.12480. Epub 2024 Sep 12.
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long-lasting and difficult to treat. The development of treatments for social impairment is critical for the treatment of several psychiatric disorders. "Amyloban 3399," a product extracted from the mushroom Hericium erinaceus, markedly improves social dysfunctions in patients with treatment-resistant schizophrenia and depression. However, the molecular mechanism(s) through which amyloban ameliorates social impairment remains unclear. To clarify this mechanism, in this study, we aimed to establish a mouse model of social defeat stress (SDS) and investigate the effects of amyloban on social deficits. Amyloban administration ameliorated social deficits and the dopamine system activity in SDS mice. These findings suggest that there is a possibility that amyloban may improve social deficits by suppressing the hyperactivation of the dopaminergic system. Amyloban may be an effective treatment for social dysfunctions associated with various psychiatric disorders.
社交功能障碍在包括抑郁症、精神分裂症和自闭症在内的各种精神疾病中很常见，且持续时间长且难以治疗。针对社交障碍的治疗方法的开发对于多种精神疾病的治疗至关重要。从猴头菇中提取的一种产品“Amyloban 3399”能显著改善难治性精神分裂症和抑郁症患者的社交功能障碍。然而，Amyloban改善社交障碍的分子机制仍不清楚。为了阐明这一机制，在本研究中，我们旨在建立一种社会挫败应激（SDS）小鼠模型，并研究Amyloban对社交缺陷的影响。给予Amyloban可改善SDS小鼠的社交缺陷和多巴胺系统活性。这些发现表明，Amyloban有可能通过抑制多巴胺能系统的过度激活来改善社交缺陷。Amyloban可能是治疗与各种精神疾病相关的社交功能障碍的有效方法。
