Mezri Sameh, Jemli Safa, Zitouni Chaima, Thabet Wadii
ENT Department, Military Hospital of Tunis, Tunis, Tunisia.
ENT Department, Tahar Sfar Hospital Mahdia, Mahdia, Tunisia.
Ear Nose Throat J. 2024 Sep 12:1455613241276766. doi: 10.1177/01455613241276766.
The coexistence of tuberculosis (TB) and malignancy within the same lymph node is a rare, if not exceptional, pathology, with only a few cases reported. We collected patients who presented concomitant TB and malignancy within the same cervical lymph node diagnosed during the period (2010-2023). Ten patients were included. They received or were receiving treatment for cancer or TB in 7 cases. All patients presented with recurrent or new lymph nodes despite being under treatment. The 3 remaining patients did not have a history of cancer or TB. Histopathological examination confirmed the coexistence of TB and malignancy within the same lymph node. Histological types of diagnosed cancers included laryngeal squamous cell carcinoma, papillary thyroid carcinoma, nasopharyngeal carcinoma, medullary carcinoma of the thyroid gland, Hodgkin lymphoma, and non-Hodgkin lymphoma. All patients received treatment for TB and cancer. Two patients died from septic complication in 1 case and from pulmonary complication due to miliary TB in 1 case. Concomitant TB and malignancy are possible, especially in countries with a high incidence of TB. Immunocompromised states related to cancer, and its treatments can add the risk of flare-up of a latent infection.
结核（TB）与恶性肿瘤在同一淋巴结中共存是一种罕见的病理情况，即便不是罕见至极。仅有少数病例报道。我们收集了在2010年至2023年期间诊断出同一颈部淋巴结内同时存在结核和恶性肿瘤的患者。纳入了10例患者。其中7例患者正在接受或曾接受过癌症或结核治疗。尽管接受了治疗，但所有患者均出现了复发性或新的淋巴结。其余3例患者无癌症或结核病史。组织病理学检查证实同一淋巴结内存在结核与恶性肿瘤并存。诊断出的癌症组织学类型包括喉鳞状细胞癌、甲状腺乳头状癌、鼻咽癌、甲状腺髓样癌、霍奇金淋巴瘤和非霍奇金淋巴瘤。所有患者均接受了结核和癌症治疗。1例患者死于败血症并发症，1例患者死于粟粒性结核引起的肺部并发症。结核与恶性肿瘤可能同时存在，尤其是在结核高发国家。与癌症及其治疗相关的免疫功能低下状态会增加潜伏感染复发的风险。
