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本文引用的文献

1
Sedation indicated?-rethinking existential suffering: a narrative review.是否需要镇静?——重新思考存在性痛苦:叙事性综述。
Ann Palliat Med. 2024 Mar;13(2):397-414. doi: 10.21037/apm-23-474. Epub 2024 Feb 27.
2
Revised European Association for Palliative Care (EAPC) recommended framework on palliative sedation: An international Delphi study.修订后的欧洲姑息治疗协会(EAPC)推荐的姑息性镇静框架:一项国际德尔菲研究。
Palliat Med. 2024 Feb;38(2):213-228. doi: 10.1177/02692163231220225. Epub 2024 Jan 31.
3
Expert-approved best practice recommendations on the use of sedative drugs and intentional sedation in specialist palliative care (SedPall).专家认可的关于在专科姑息治疗中使用镇静药物和(有意识的)镇静的最佳实践推荐(SedPall)。
BMC Palliat Care. 2023 Sep 4;22(1):126. doi: 10.1186/s12904-023-01243-z.
4
Review of European Guidelines on Palliative Sedation: A Foundation for the Updating of the European Association for Palliative Care Framework.欧洲缓和医疗镇静指南回顾:为更新欧洲姑息治疗协会框架奠定基础。
J Palliat Med. 2022 Nov;25(11):1721-1731. doi: 10.1089/jpm.2021.0646. Epub 2022 Jul 12.
5
Intentional Sedation as a Means to Ease Suffering: A Systematically Constructed Terminology for Sedation in Palliative Care.以镇静为手段减轻痛苦:缓和医疗中镇静的系统构建术语。
J Palliat Med. 2022 May;25(5):793-796. doi: 10.1089/jpm.2021.0428. Epub 2022 Jan 21.
6
The Decision-Making Process for Palliative Sedation for Patients with Advanced Cancer-Analysis from a Systematic Review of Prospective Studies.晚期癌症患者姑息性镇静的决策过程——基于前瞻性研究系统评价的分析
Cancers (Basel). 2022 Jan 8;14(2):301. doi: 10.3390/cancers14020301.
7
To hydrate or not to hydrate? The effect of hydration on survival, symptoms and quality of dying among terminally ill cancer patients.是否需要补水?水合作用对终末期癌症患者生存、症状和临终质量的影响。
BMC Palliat Care. 2021 Jan 12;20(1):13. doi: 10.1186/s12904-021-00710-9.
8
How to measure the effects and potential adverse events of palliative sedation? An integrative review.如何衡量姑息性镇静的效果和潜在不良事件?一项综合综述。
Palliat Med. 2021 Feb;35(2):295-314. doi: 10.1177/0269216320974264. Epub 2020 Dec 14.
9
Clinical Aspects of Palliative Sedation in Prospective Studies. A Systematic Review.前瞻性研究中姑息性镇静的临床方面。系统评价。
J Pain Symptom Manage. 2021 Apr;61(4):831-844.e10. doi: 10.1016/j.jpainsymman.2020.09.022. Epub 2020 Sep 19.
10
Association between continuous deep sedation and survival time in terminally ill cancer patients.终末期癌症患者持续深度镇静与生存时间的关系。
Support Care Cancer. 2021 Jan;29(1):525-531. doi: 10.1007/s00520-020-05516-8. Epub 2020 May 15.

[姑息性镇静的新建议]

[New recommendations on palliative sedation].

作者信息

Surges Séverine Marie, Brunsch Holger, Przyborek Marta, Jaspers Birgit, Radbruch Lukas

机构信息

Klinik für Palliativmedizin, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Bonner Netzwerk für Versorgungsforschung, Universität Bonn, Bonn, Deutschland.

出版信息

Schmerz. 2024 Oct;38(5):365-373. doi: 10.1007/s00482-024-00825-x. Epub 2024 Sep 12.

DOI:10.1007/s00482-024-00825-x
PMID:39264452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11420285/
Abstract

Palliative sedation aims to relieve refractory suffering in patients with life-limiting disease. The 2009 framework on palliative sedation of the European Association for Palliative Care (EAPC) has recently been updated. Recommendations have also been formulated by the research group SedPall in Germany. This article describes the social and ethical complexity of decision-making and summarises the recommendations. Patient autonomy is emphasised. Refractoriness of the suffering should be determined jointly by physician and patient. Sedation should be proportional, that is to say, its form and duration should be adapted to the patient's individual situation. The decision on palliative sedation and that on hydration involve two separate decision-making processes. Midazolam should be used as first choice. Particular attention should be paid to the patient's relatives/significant others and the treating team.

摘要

姑息性镇静旨在缓解患有危及生命疾病患者的顽固性痛苦。欧洲姑息治疗协会(EAPC)2009年的姑息性镇静框架最近已更新。德国的SedPall研究小组也制定了相关建议。本文描述了决策过程中的社会和伦理复杂性,并总结了这些建议。强调了患者的自主权。痛苦的顽固性应由医生和患者共同确定。镇静应适度,也就是说,其形式和持续时间应根据患者的个体情况进行调整。关于姑息性镇静的决定和关于补液的决定涉及两个独立的决策过程。应首选咪达唑仑。应特别关注患者的亲属/重要他人以及治疗团队。