记住少突胶质细胞：揭示它们在阿尔茨海默病中被忽视的作用。

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

机构信息

Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

出版信息

PLoS Biol. 2024 Sep 12;22(9):e3002798. doi: 10.1371/journal.pbio.3002798. eCollection 2024 Sep.

DOI:10.1371/journal.pbio.3002798

PMID:39264958

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11421816/

Abstract

Our understanding of Alzheimer's disease (AD) has evolved from focusing solely on neurons to recognizing the role of glia. A recent study in PLOS Biology revealed that oligodendrocytes are an important source of Aβ that impairs neuronal function.

摘要

我们对阿尔茨海默病（AD）的理解已经从单纯关注神经元发展到认识到神经胶质的作用。最近发表在《PLOS Biology》上的一项研究表明，少突胶质细胞是 Aβ的一个重要来源，它会损害神经元功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/901f/11421816/9c6232466558/pbio.3002798.g001.jpg

相似文献

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

PLoS Biol. 2024 Sep 12;22(9):e3002798. doi: 10.1371/journal.pbio.3002798. eCollection 2024 Sep.

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.

Nat Neurosci. 2024 Sep;27(9):1668-1674. doi: 10.1038/s41593-024-01730-3. Epub 2024 Aug 5.

The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.

Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13.

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.

PLoS Biol. 2024 Jul 23;22(7):e3002727. doi: 10.1371/journal.pbio.3002727. eCollection 2024 Jul.

Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation.

Biol Res. 2005;38(4):381-7. doi: 10.4067/s0716-97602005000400011.

Increased GADD34 in oligodendrocytes in Alzheimer's disease.

Neurosci Lett. 2015 Aug 18;602:50-5. doi: 10.1016/j.neulet.2015.06.052. Epub 2015 Jul 2.

Amyloid-beta peptides are cytotoxic to oligodendrocytes.

J Neurosci. 2001 Jan 1;21(1):RC118. doi: 10.1523/JNEUROSCI.21-01-j0001.2001.

Oligodendrocytes are a novel source of amyloid peptide generation.

Neurochem Res. 2009 Dec;34(12):2243-50. doi: 10.1007/s11064-009-0022-9.

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.

Acta Neuropathol. 2010 May;119(5):523-41. doi: 10.1007/s00401-010-0679-9. Epub 2010 Mar 31.

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.

Mol Cells. 2019 Nov 30;42(11):739-746. doi: 10.14348/molcells.2019.0200.

引用本文的文献

The immunological role of oligodendrocytes: beyond myelin maintenance.

Discov Immunol. 2025 Apr 28;4(1):kyaf005. doi: 10.1093/discim/kyaf005. eCollection 2025.

本文引用的文献

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.

Nat Neurosci. 2024 Sep;27(9):1668-1674. doi: 10.1038/s41593-024-01730-3. Epub 2024 Aug 5.

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.

PLoS Biol. 2024 Jul 23;22(7):e3002727. doi: 10.1371/journal.pbio.3002727. eCollection 2024 Jul.

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Nat Neurosci. 2024 Aug;27(8):1468-1474. doi: 10.1038/s41593-024-01682-8. Epub 2024 Jun 27.

Early Alzheimer's disease pathology in human cortex involves transient cell states.

Cell. 2023 Sep 28;186(20):4438-4453.e23. doi: 10.1016/j.cell.2023.08.005.

Membrane lipid remodeling modulates γ-secretase processivity.

J Biol Chem. 2023 Apr;299(4):103027. doi: 10.1016/j.jbc.2023.103027. Epub 2023 Feb 16.

CD8 T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging.

Nat Neurosci. 2022 Nov;25(11):1446-1457. doi: 10.1038/s41593-022-01183-6. Epub 2022 Oct 24.

Disease-associated oligodendrocyte responses across neurodegenerative diseases.

Cell Rep. 2022 Aug 23;40(8):111189. doi: 10.1016/j.celrep.2022.111189.

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies.

Nat Neurosci. 2022 Jul;25(7):876-886. doi: 10.1038/s41593-022-01104-7. Epub 2022 Jun 27.

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.

Nat Med. 2020 Jan;26(1):131-142. doi: 10.1038/s41591-019-0695-9. Epub 2020 Jan 13.

Myelin in the Central Nervous System: Structure, Function, and Pathology.

Physiol Rev. 2019 Jul 1;99(3):1381-1431. doi: 10.1152/physrev.00031.2018.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

记住少突胶质细胞：揭示它们在阿尔茨海默病中被忽视的作用。

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

记住少突胶质细胞：揭示它们在阿尔茨海默病中被忽视的作用。

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献