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由2-氨基-3-甲基咪唑[4,5-f]喹啉诱导的大鼠肝细胞癌中的活化癌基因。

Activated oncogenes in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

作者信息

Ishikawa F, Takaku F, Nagao M, Ochiai M, Hayashi K, Takayama S, Sugimura T

出版信息

Jpn J Cancer Res. 1985 Jun;76(6):425-8.

PMID:3926575
Abstract

The presence of activated oncogenes in several rat hepatocellular carcinomas induced by 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) was examined by NIH 3T3 cell transfection assay and Southern blot analysis. In one tumor, IQ4, rat H-ras-1 and another oncogene that did not belong to the ras family were found to be activated.

摘要

通过NIH 3T3细胞转染试验和Southern印迹分析，检测了2-氨基-3-甲基咪唑[4,5-f]喹啉（IQ）诱导的几种大鼠肝细胞癌中活化癌基因的存在情况。在一个名为IQ4的肿瘤中，发现大鼠H-ras-1和另一个不属于ras家族的癌基因被激活。

相似文献

1
Activated oncogenes in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.由2-氨基-3-甲基咪唑[4,5-f]喹啉诱导的大鼠肝细胞癌中的活化癌基因。
Jpn J Cancer Res. 1985 Jun;76(6):425-8.
2
Activated c-raf gene in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.2-氨基-3-甲基咪唑[4,5-f]喹啉诱导的大鼠肝细胞癌中激活的c-raf基因
Biochem Biophys Res Commun. 1985 Oct 15;132(1):186-92. doi: 10.1016/0006-291x(85)91005-8.
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Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline.食物诱变剂2-氨基-3-甲基咪唑[4,5-f]喹啉诱导非人类灵长类动物发生肝细胞癌
Environ Health Perspect. 1994 Feb;102(2):190-3. doi: 10.1289/ehp.94102190.

引用本文的文献

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World J Gastroenterol. 1997 Dec 15;3(4):213-7. doi: 10.3748/wjg.v3.i4.213.
2
Past, present, and future of mutagens in cooked foods.熟食中诱变剂的过去、现在与未来。
Environ Health Perspect. 1986 Aug;67:5-10. doi: 10.1289/ehp.86675.
3
Rapid detection of xenotransplanted human tissues using in situ hybridization.使用原位杂交技术快速检测异种移植的人体组织。
Am J Pathol. 1986 Mar;122(3):386-91.
4
Human cancer and cellular oncogenes.人类癌症与细胞癌基因。
Biochem J. 1987 Apr 15;243(2):313-27. doi: 10.1042/bj2430313.
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Molecular cloning of an oncogene from a human hepatocellular carcinoma.从人肝细胞癌中克隆一个癌基因
Proc Natl Acad Sci U S A. 1986 Jul;83(14):4993-7. doi: 10.1073/pnas.83.14.4993.
6
Activation of rat c-raf during transfection of hepatocellular carcinoma DNA.在转染肝癌DNA过程中大鼠c-raf的激活。
Proc Natl Acad Sci U S A. 1986 May;83(10):3209-12. doi: 10.1073/pnas.83.10.3209.
7
Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes.猿猴病毒40-肝细胞系的致瘤性：体外和体内传代对肝脏特异性基因及癌基因表达的影响
Mol Cell Biol. 1988 Oct;8(10):4492-501. doi: 10.1128/mcb.8.10.4492-4501.1988.
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