Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 04514, Republic of Korea; Institute of Medical Research, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 04514, Republic of Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 04514, Republic of Korea; Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06355, Republic of Korea.
J Affect Disord. 2025 Jan 1;368:82-89. doi: 10.1016/j.jad.2024.09.050. Epub 2024 Sep 13.
Understanding the association between the menopausal transition and declining sleep quality can guide optimal timing for preventive interventions in transitioning women. However, studies lack representation of Asian women and sufficient data on the progression of menopausal stages and sleep quality changes over time in this population.
This study included 3305 women in the pre-menopause stage at baseline. The sleep quality and its components were assessed using the Pittsburgh Sleep Quality Index (PSQI). Menopausal stages were classified as pre-menopause, early transition, late transition, and post-menopause according to the Stages of Reproductive Aging Workshop+10 (STRAW+10) criteria. We estimated the longitudinal association between menopausal stage changes over time and the PSQI score, and examined the effect of being overweight.
The trends in the PSQI scores and its components according to the menopausal stage changes over time showed that with the exception of sleep duration and habitual sleep efficiency, an overall decline was noted in sleep health during late transition and post-menopause compared to pre-menopause. These associations were independent of time-variant annual chronological aging, which was not significantly associated with sleep deterioration. Additionally, although the associations between menopausal stages and sleep quality did not significantly differ by adiposity level, the overweight group exhibited worse PSQI scores and components than did the non-overweight group.
Sleep quality and menopausal stage were assessed using self-reported questionnaires without objective measures.
Our study underscores the importance of screening for sleep quality deterioration and implementing appropriate measures for women experiencing menopausal transition.
了解绝经过渡期与睡眠质量下降之间的关系，可以指导在过渡阶段的女性中进行预防性干预的最佳时机。然而，这些研究缺乏亚洲女性的代表性，也缺乏关于该人群绝经阶段进展和睡眠质量随时间变化的数据。
本研究纳入了基线时处于绝经前阶段的 3305 名女性。使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量及其组成部分。根据生殖衰老工作坊+10 （STRAW+10）标准，将绝经阶段分为绝经前、早期过渡、晚期过渡和绝经后。我们估计了随时间推移绝经阶段变化与 PSQI 评分之间的纵向关联，并检查了超重的影响。
根据随时间推移的绝经阶段变化的 PSQI 评分及其组成部分的趋势表明，除了睡眠时间和习惯性睡眠效率外，与绝经前相比，在晚期过渡和绝经后，睡眠健康总体呈下降趋势。这些关联独立于时间变化的年度生理年龄，与睡眠恶化无显著关联。此外，尽管绝经阶段与睡眠质量之间的关联不受肥胖水平的影响，但超重组的 PSQI 评分和组成部分比非超重组差。
睡眠质量和绝经阶段是通过自我报告的问卷评估的，没有客观测量。
我们的研究强调了筛查睡眠质量恶化和为经历绝经过渡的女性实施适当措施的重要性。
