Charles Sturt University School of Agricultural, Environmental and Veterinary Sciences, Wagga Wagga, New South Wales, Australia.
Scone Equine Hospital, Scone, New South Wales, Australia.
J Vet Intern Med. 2024 Sep-Oct;38(5):2718-2728. doi: 10.1111/jvim.17185. Epub 2024 Sep 12.
Diarrhea in foals can be associated with disruption of the intestinal microbiota (dysbiosis). Effective management of intestinal dysbiosis in foals has not been demonstrated.
HYPOTHESIS/OBJECTIVES: Fecal microbiota transplantation (FMT) in foals with diarrhea influences the intestinal microbiota and improves clinical and clinicopathological outcomes.
Twenty-five foals <6 months of age with diarrhea and systemic inflammatory response syndrome at 3 veterinary hospitals.
A prospective randomized placebo-controlled cohort study. Foals in the FMT group (n = 19) or control group (n = 9) received FMT or electrolyte solution once daily for 3 days. Fecal samples were obtained on Day 0 (D0), D1, D2, D3, and D7. Within group and between group data analyses were performed for clinical, clinicopathological, and microbiota variables.
Treatment had no effect on survival (FMT 79%; control 100%, P = .3) or resolution of diarrhea (FMT 68%; control 55%, P = .4). On D3, the white blood cell count of the FMT group was lower than the control group (D3 FMT group median 6.4 g/L [5-8.3 g/L]; D3 control group median 14.3 g/L [6.7-18.9 g/L] P = .04). Heart rate reduced over time in the FMT group (D0 median 80 bpm [60-150 bpm]; D2 median 70 bpm [52-110 bpm] [P = .005]; and D3 median 64, [54-102 bpm] [P < .001]). Phylum Verrucomicrobiota, genus Akkermansia, and family Prevotellaceae were enriched in the FMT group on D1 (linear discriminate analysis > 4).
In foals with diarrhea, FMT appears safe and can be associated with some clinical and microbiota changes suggestive of beneficial effect.
幼驹腹泻可能与肠道微生物群失调（肠道生态失调）有关。尚未证实有效治疗幼驹肠道生态失调。
假设/目的：粪便微生物群移植（FMT）治疗腹泻幼驹可影响肠道微生物群，并改善临床和临床病理结局。
3 家兽医医院的 25 头＜6 月龄、腹泻伴全身炎症反应综合征的幼驹。
前瞻性随机安慰剂对照队列研究。FMT 组（n = 19）或对照组（n = 9）的幼驹每天接受 FMT 或电解质溶液治疗 3 天，1 次/d。于第 0 天（D0）、D1、D2、D3 和 D7 采集粪便样本。对临床、临床病理和微生物组变量进行组内和组间数据分析。
治疗对存活率（FMT 组 79%；对照组 100%，P = .3）或腹泻缓解（FMT 组 68%；对照组 55%，P = .4）均无影响。在 D3，FMT 组的白细胞计数低于对照组（D3 FMT 组中位数 6.4 g/L[5-8.3 g/L]；D3 对照组中位数 14.3 g/L[6.7-18.9 g/L]，P = .04）。FMT 组的心率随时间逐渐降低（D0 中位数 80 bpm[60-150 bpm]；D2 中位数 70 bpm[52-110 bpm]，P = .005；D3 中位数 64，bpm[54-102 bpm]，P < .001）。FMT 组在 D1 时厚壁菌门、阿克曼氏菌属和普雷沃氏菌科富集（线性判别分析 > 4）。
在腹泻幼驹中，FMT 似乎是安全的，并可能与一些临床和微生物群变化相关，这些变化提示有益效果。
