Cantas Leon, Goll Rasmus, Fenton Christopher G, Paulssen Ruth H, Sørum Henning
PrivateVET Small Animal Clinic, Norwegian Private Veterinary Services, Hammerfest, Norway.
Biocode Bank Norway, Hammerfest, Norway.
Front Vet Sci. 2025 Jul 1;12:1505226. doi: 10.3389/fvets.2025.1505226. eCollection 2025.
The digestive tract hosts a variety of microorganisms. These microorganisms "" play multiple crucial roles in physiological, immunological, and metabolic processes in the body. The manipulation and transplantation of "" have lately gained increasing interest in human medicine with promising clinical outcomes, whereas much less is known in veterinary practice.
The goals of this pilot study were to evaluate the safety and impact of Fecal Microbiota Transplantation (FMT) for dogs suffering from non-infectious digestive disorders.
Seven client-owned adult dogs with idiopathic persistent diarrhea (>3 weeks) and very poor skin-coat conditions received the intervention (FMT) and were evaluated in a private veterinary clinic.
Transplants have been taken from healthy donors and were administered rectally to recipients. Objective clinical examinations with analyses of blood and feces samples on day 0 (pre-FMT) and days 14-28 (post-FMT) were performed. Besides the conventional blood hematology and biochemistry analyses, 16S sequencing analysis was used in fecal samples.
No FMT-related complications occurred. Five of seven (71%) patients demonstrated improved fecal parameters associated with better overall clinical outcome, whereas four of the five (80%) recovered recipients showed molecular correlation with the donor gut microbiota after rectal FMT. There were insignificant changes shown for the conventionally analyzed blood samples. The serum cobalamin levels showed a tendency to increase in recovered recipients.
FMT was easy to apply and displayed certain health benefits in this study. Our findings reveal the important role of a gut microbiome balance in the overall health of dogs. Further research is needed to identify the dynamics and interplay between the different bacterial phyla that may have an impact on the stimuli of host immunologic and metabolic responses.
消化道中存在多种微生物。这些微生物在机体的生理、免疫和代谢过程中发挥着多种关键作用。微生物的操控和移植最近在人类医学中引起了越来越多的关注，并取得了有前景的临床结果，而在兽医实践中对此了解较少。
本初步研究的目的是评估粪便微生物群移植（FMT）对患有非感染性消化系统疾病的犬的安全性和影响。
7只客户拥有的成年犬，患有特发性持续性腹泻（>3周）且皮肤毛发状况很差，接受了干预（FMT），并在一家私人兽医诊所接受评估。
移植样本取自健康供体，并通过直肠给药给受体。在第0天（FMT前）以及第14 - 28天（FMT后）进行了客观的临床检查，并对血液和粪便样本进行分析。除了常规的血液血液学和生化分析外，还对粪便样本进行了16S测序分析。
未发生与FMT相关的并发症。7只患者中有5只（71%）粪便参数得到改善，整体临床结果更好，而5只康复的受体中有4只（80%）在直肠FMT后显示出与供体肠道微生物群的分子相关性。常规分析的血液样本显示变化不显著。康复受体的血清钴胺素水平有升高趋势。
在本研究中，FMT易于应用并显示出一定的健康益处。我们的研究结果揭示了肠道微生物群平衡在犬整体健康中的重要作用。需要进一步研究以确定不同细菌门类之间可能影响宿主免疫和代谢反应刺激的动态变化和相互作用。
