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髋臼发育不良患儿骨核体积变化与术后缺血性坏死风险的相关性。

Association between ossific nucleus volume changes and postoperative avascular necrosis risk in children with developmental dysplasia of the hip.

机构信息

Pediatric Orthopaedic Hospital, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.

Department of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

出版信息

Sci Rep. 2024 Sep 12;14(1):21363. doi: 10.1038/s41598-024-72445-5.

Abstract

This study aimed to investigate the correlation between ossific nucleus volume and avascular necrosis (AVN) in pediatric patients diagnosed with developmental dysplasia of the hip (DDH). Analyzing 211 cases, including 119 open reduction (OR) and 92 closed reduction (CR) procedures, we quantified ossific nucleus volume using magnetic resonance imaging (MRI). Categorizing the OR group based on ossific nucleus volume revealed no statistically significant difference in AVN incidence. Similarly, in the CR cohort, there was no significant discrepancy in AVN occurrence between subgroups with or without the ossific nucleus. Logistic regression in CR identified the international hip dysplasia institute (IHDI) grade as a significant AVN risk factor (p = 0.007). IHDI grades 3 and 4 exhibited a 6.94 times higher likelihood of AVN compared to grades 1 and 2. Across CR and OR, neither initial age nor ossific nucleus volume emerged as AVN risk factors. In conclusion, ossific nucleus volume does not pose a risk for AVN in DDH children undergoing CR or OR, emphasizing the clinical significance of IHDI grading in predicting AVN risk during CR and the importance of early intervention to prevent treatment delays.

摘要

本研究旨在探讨发育性髋关节发育不良(DDH)患儿骨核体积与缺血性坏死(AVN)之间的相关性。通过分析 211 例病例,包括 119 例切开复位(OR)和 92 例闭合复位(CR)手术,我们使用磁共振成像(MRI)对骨核体积进行了量化。根据骨核体积对 OR 组进行分类,发现 AVN 发生率无统计学差异。同样,在 CR 队列中,有骨核的亚组与无骨核的亚组之间,AVN 的发生没有显著差异。CR 中的逻辑回归确定国际髋关节发育不良研究所(IHDI)分级是 AVN 的一个显著危险因素(p=0.007)。与 1 级和 2 级相比,3 级和 4 级的 IHDI 发生 AVN 的可能性高 6.94 倍。在 CR 和 OR 中,初始年龄和骨核体积均不是 AVN 的危险因素。总之,CR 或 OR 治疗的 DDH 患儿的骨核体积不会增加 AVN 的风险,这强调了 IHDI 分级在预测 CR 中 AVN 风险方面的临床意义,以及早期干预以预防治疗延误的重要性。

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