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经鼻内注射透明质酸治疗鼻内瓣膜塌陷

Internal Nasal Valve Collapse Treatment by Endonasal Hyaluronic Acid Injection.

作者信息

Gagnieur Pierre, Fieux Maxime, Saloner Laurie, Louis Bruno, Vertu-Ciolino Delphine, Mojallal Alain-Ali

机构信息

Service de chirurgie maxillo-faciale et plastique de la face, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, F-69495, Pierre Bénite cedex, France.

Service d'ORL d'otoneurochirurgie et de chirurgie cervico-faciale, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, F-69495, Pierre Bénite cedex, France.

出版信息

Aesthetic Plast Surg. 2025 Apr;49(8):2227-2234. doi: 10.1007/s00266-024-04186-9. Epub 2024 Sep 12.

Abstract

OBJECTIVE

Internal nasal valve collapse (IVC) is a common functional complication of rhinoplasty and injecting hyaluronic acid is one of the treatment options available, but its effectiveness has never been evaluated. The objective of this study was to assess the evolution of IVC after injection of hyaluronic acid using objective and subjective measures of nasal obstruction.

STUDY DESIGN

A prospective interventional study was conducted.

METHODS

Adult patients consulting for nasal obstruction after (septo)rhinoplasty and diagnosed with IVC were included. Patients underwent 4-phase rhinomanometry, completed nasal obstruction symptoms evaluation (NOSE) and visual analog scale (VAS) questionnaires and received hyaluronic acid injections. Measurements were repeated immediately, one month and one year later. The primary outcome measure was the proportion of patients below the rhinomanometric diagnostic threshold for IVC at one month.

RESULTS

Among the 22 patients included, 20 (91%) had rhinomanometry measurements below the diagnostic threshold for IVC one month after injection. It decreased to 53% (8/15 patients) at one year post injection. The mean NOSE score decreased from 74.5 (± 18.0) before injection to 35.2 (± 23.3) after injection (p < 0.0001). The mean VAS score decreased from 7.0 (± 1.4) before injection to 3.4 (± 1.9) after injection (p < 0.0001). In these patients with post-(septo)rhinoplasty IVC, hyaluronic acid injection into the internal nasal valve substantially improved subjective and objective measures of nasal obstruction.

CONCLUSION

These results suggest hyaluronic acid injection (performed as described) is an effective treatment for IVC and is an excellent alternative to surgical treatment.

LEVEL OF EVIDENCE III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .

摘要

目的

鼻内瓣膜塌陷(IVC)是隆鼻手术常见的功能性并发症,注射透明质酸是可用的治疗选择之一,但其有效性从未得到评估。本研究的目的是通过客观和主观的鼻阻塞测量方法,评估注射透明质酸后IVC的演变情况。

研究设计

进行了一项前瞻性干预研究。

方法

纳入在(鼻中隔)隆鼻术后因鼻阻塞前来咨询且被诊断为IVC的成年患者。患者接受了四阶段鼻阻力测量,完成鼻阻塞症状评估(NOSE)和视觉模拟量表(VAS)问卷,并接受透明质酸注射。在注射后即刻、1个月和1年后重复测量。主要结局指标是注射后1个月时鼻阻力测量低于IVC诊断阈值的患者比例。

结果

在纳入的22例患者中,20例(91%)在注射后1个月时鼻阻力测量低于IVC诊断阈值。注射后1年时降至53%(15例患者中的8例)。平均NOSE评分从注射前的74.5(±18.0)降至注射后的35.2(±23.3)(p<0.0001)。平均VAS评分从注射前的7.0(±1.4)降至注射后的3.4(±1.9)(p<0.0001)。在这些(鼻中隔)隆鼻术后发生IVC的患者中,向鼻内瓣膜注射透明质酸显著改善了鼻阻塞的主观和客观测量指标。

结论

这些结果表明,(按所述方法进行的)透明质酸注射是治疗IVC的有效方法,是手术治疗的极佳替代方案。

证据水平III:本刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述,请参阅目录或在线作者指南https://www.springer.com/00266

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f6/12069151/e3f16faffb8c/266_2024_4186_Fig1_HTML.jpg

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