Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
Section on Intercellular Interactions, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Front Immunol. 2024 Aug 29;15:1446730. doi: 10.3389/fimmu.2024.1446730. eCollection 2024.
Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.
对 30 名被鉴定为精英控制者（15 名一过性控制者[在失去病毒控制前平均研究了 1.38 年]和 15 名持续性控制者）的 HIV 感染者（PWH）进行了血浆细胞因子水平的定量检测。还对 30 名未经抗逆转录病毒治疗（ART）的 PWH、30 名病毒载量未检出的接受 ART 治疗的 PWH 和 30 名 HIV 未感染者进行了研究。与对照组相比，PWH 中的细胞因子水平更高，EC 显示出最高水平。一过性控制者中发现 IP-10 和 MIG 水平升高，是病毒控制丧失的预测指标。这些发现为预测 EC 中的病毒学结果和控制丧失提供了可行的生物标志物。
