Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark.
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark.
Int J Antimicrob Agents. 2019 Jun;53(6):716-723. doi: 10.1016/j.ijantimicag.2019.02.015. Epub 2019 Feb 27.
Resveratrol is a naturally occurring polyphenolic antioxidant that has received massive attention for its potential health benefits, including anticarcinogenesis, anti-aging and antimicrobial properties. The compound is well tolerated by humans and in recent years has been widely used as a nutraceutical. Its common use makes it interesting to investigate with respect to antimicrobial properties both as a single agent and in combination with conventional antibiotics. Resveratrol displays antimicrobial activity against a surprisingly wide range of bacterial, viral and fungal species. At subinhibitory concentrations, resveratrol can alter bacterial expression of virulence traits leading to reduced toxin production, inhibition of biofilm formation, reduced motility and interference with quorum sensing. In combination with conventional antibiotics, resveratrol enhances the activity of aminoglycosides against Staphylococcus aureus, whereas it antagonises the lethal activity of fluoroquinolones against S. aureus and Escherichia coli. Whilst the antimicrobial properties of the compound have been extensively studied in vitro, little is known about its efficacy in vivo. Nonetheless, following topical application resveratrol has alleviated acne lesions caused by the bacterium Propionibacterium acnes. There are currently no in vivo studies addressing its effect in combination with antibiotics, but recent research suggests that there may be a potential for enhancing the antimicrobial efficacy of certain existing antibiotic classes in combination with resveratrol. Given the difficulties associated with introducing new antimicrobial agents to the market, nutraceuticals such as resveratrol may prove to be interesting candidates when searching for solutions for the growing problem of antimicrobial resistance.
白藜芦醇是一种天然存在的多酚类抗氧化剂，因其潜在的健康益处而受到广泛关注，包括抗癌、抗衰老和抗菌特性。该化合物在人类中耐受性良好，近年来已被广泛用作营养保健品。由于其常见的用途，研究其作为单一药物以及与传统抗生素联合使用的抗菌特性变得很有趣。白藜芦醇对范围广泛的细菌、病毒和真菌物种显示出抗菌活性。在亚抑菌浓度下，白藜芦醇可以改变细菌表达毒力特征，导致毒素产生减少、生物膜形成抑制、运动性降低和群体感应干扰。与传统抗生素联合使用时，白藜芦醇增强了氨基糖苷类药物对金黄色葡萄球菌的活性，而拮抗了氟喹诺酮类药物对金黄色葡萄球菌和大肠杆菌的致死活性。尽管该化合物的抗菌特性已在体外得到广泛研究，但对其体内疗效知之甚少。尽管如此，局部应用白藜芦醇后，痤疮丙酸杆菌引起的痤疮病变得到了缓解。目前尚无关于其与抗生素联合使用的体内研究，但最近的研究表明，与白藜芦醇联合使用可能有潜力增强某些现有抗生素类别的抗菌功效。鉴于将新的抗菌剂引入市场所面临的困难，营养保健品如白藜芦醇在寻找解决日益严重的抗菌耐药性问题的方法时可能是一个有趣的候选者。
