Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Department of Plant Pathology and Microbiology, Institute of Environmental Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Microb Biotechnol. 2024 Sep;17(9):e70005. doi: 10.1111/1751-7915.70005.
Agricultural yields are often limited by damage caused by pathogenic microorganisms, including plant-pathogenic bacteria. The chemical control options to cope with bacterial diseases in agriculture are limited, predominantly relying on copper-based products. These compounds, however, possess limited efficacy. Therefore, there is an urgent need to develop novel technologies to manage bacterial plant diseases and reduce food loss. In this study, a new antimicrobial agent was developed using a doping method that entraps small bioactive organic molecules inside copper as the metal matrix. The food preservative agent lauroyl arginate ethyl ester (ethyl lauroyl arginate; LAE) was chosen as the doped organic compound. The new composites were termed LAE@[Cu]. Bactericidal assays against Acidovorax citrulli, a severe plant pathogen, revealed that LAE and copper in the composites possess a synergistic interaction as compared with each component individually. LAE@[Cu] composites were further characterised in terms of chemical properties and in planta assays demonstrated their potential for further development as crop protection agents.
农业产量通常受到致病微生物（包括植物病原菌）造成的损害的限制。用于应对农业中细菌病害的化学控制选项有限，主要依赖于铜基产品。然而，这些化合物的效果有限。因此，迫切需要开发新技术来管理细菌性植物病害并减少食物损失。在这项研究中，使用掺杂方法开发了一种新的抗菌剂，该方法将小生物活性有机分子包埋在铜作为金属基质内。选择食品防腐剂月桂酰精氨酸乙酯（月桂酰精氨酸乙酯；LAE）作为掺杂的有机化合物。新的复合材料被称为 LAE@[Cu]。与每种成分单独相比，针对严重植物病原体酸醋杆菌的杀菌试验表明，LAE 和复合材料中的铜具有协同作用。进一步对 LAE@[Cu]复合材料进行了化学性质的表征，并进行了植物体内试验，表明它们具有进一步开发为作物保护剂的潜力。
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