与人单克隆IgM类风湿因子重链第三高变区相对应的合成肽确定了一个免疫显性独特型。
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype.
作者信息
Goldfien R D, Chen P P, Fong S, Carson D A
出版信息
J Exp Med. 1985 Aug 1;162(2):756-61. doi: 10.1084/jem.162.2.756.
Abstract
Synthetic peptides corresponding to eight individual heavy chain complementarity-determining regions (CDR) of three human monoclonal IgM anti-IgG (rheumatoid factor [RF]) paraproteins elicited rabbit antibodies with markedly different properties. All antisera recognized the immunizing peptide, and several reacted with the isolated IgM heavy chain on immunoblots. However, only the antisera against peptides representing the third CDR bound consistently and specifically to the intact IgM-RF molecule. These data indicate that the third CDR of human mu chains comprises an immunodominant idiotype, and suggest that the D gene segment may be especially important in creating idiotypic diversity. Synthetic peptides corresponding to the third heavy chain CDR of human paraproteins may be clinically useful for the specific induction of antiidiotypic antibodies.
摘要
对应于三种人源单克隆 IgM 抗 IgG（类风湿因子 [RF]）副蛋白的八个单独重链互补决定区（CDR）的合成肽引发了具有明显不同特性的兔抗体。所有抗血清都识别免疫肽，并且有几种在免疫印迹上与分离的 IgM 重链发生反应。然而，只有针对代表第三个 CDR 的肽的抗血清始终如一地特异性结合完整的 IgM-RF 分子。这些数据表明人μ链的第三个 CDR 包含一个免疫显性独特型，并表明 D 基因片段在产生独特型多样性方面可能特别重要。对应于人副蛋白第三个重链 CDR 的合成肽在临床上可能有助于特异性诱导抗独特型抗体。
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Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype.与人单克隆IgM类风湿因子重链第三高变区相对应的合成肽确定了一个免疫显性独特型。
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引用本文的文献
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How well can an idiotope peptide mimic replace its parent idiotype in a synthetic peptide vaccine?在合成肽疫苗中，一个独特型表位肽模拟物能在多大程度上替代其亲本独特型？
Pharm Res. 2004 Aug;21(8):1480-8. doi: 10.1023/b:pham.0000036924.01527.f7.
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The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system.独特型网络与内影像：在GAT系统中，寡基因编码的Ab2（抗独特型）抗体对种系网络的可能调控。
EMBO J. 1985 Dec 30;4(13B):3681-8. doi: 10.1002/j.1460-2075.1985.tb04135.x.
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The idiotype-antiidiotype network in human autoimmunity.人类自身免疫中的独特型-抗独特型网络。
J Clin Immunol. 1985 Nov;5(6):365-9. doi: 10.1007/BF00915332.
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Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.一种人类抗巨细胞病毒抗体克隆重链和轻链可变区的完整蛋白质序列，与Wa独特型家族的人类单克隆类风湿因子显示出惊人的相似性。
J Clin Invest. 1988 May;81(5):1511-8. doi: 10.1172/JCI113483.
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Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.来自Wa独特型家族的两种人IgM类风湿因子BOR和KAS可变区的完整氨基酸序列，揭示了重链和轻链可变区及连接区基因片段的有限使用情况。
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本文引用的文献
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Human immunoglobulin D segments encoded in tandem multigenic families.串联多基因家族中编码的人类免疫球蛋白D区段。
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The D segment defines the T15 idiotype: the immunoresponse of A/J mice to Pneumococcus pneumoniae.D 区段定义了 T15 独特型：A/J 小鼠对肺炎链球菌的免疫反应。
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Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.用人抗合成肽抗体描绘人自身抗体上的交叉反应独特型。
J Exp Med. 1984 May 1;159(5):1502-11. doi: 10.1084/jem.159.5.1502.
6
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes.由特定肽诱导产生的抗高变区抗体：一种研究独特型结构相关性的方法。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1784-8. doi: 10.1073/pnas.81.6.1784.
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Galactan-binding antibodies. Diversity and structure of idiotypes.半乳聚糖结合抗体。独特型的多样性与结构。
J Exp Med. 1983 Nov 1;158(5):1385-400. doi: 10.1084/jem.158.5.1385.
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Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies.κIIIb轻链与单克隆人IgMκ自身抗体的优先缔合。
J Immunol. 1983 Sep;131(3):1322-5.
9
Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.来自Wa交叉独特型组的两种单克隆人抗γ球蛋白可变区的完整氨基酸序列：关于J片段参与独特型结构关联的推测
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3799-803. doi: 10.1073/pnas.78.6.3799.
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Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran.小鼠抗α-(1→3)葡聚糖抗体上交叉反应性和个体独特型决定簇的结构关联
J Exp Med. 1980 May 1;151(5):1059-70. doi: 10.1084/jem.151.5.1059.
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