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1
Galactan-binding antibodies. Diversity and structure of idiotypes.半乳聚糖结合抗体。独特型的多样性与结构。
J Exp Med. 1983 Nov 1;158(5):1385-400. doi: 10.1084/jem.158.5.1385.
2
Immunochemical and molecular characterization of regulatory idiotopes expressed by monoclonal antibodies exhibiting or lacking beta 2-6 fructosan binding activity.具有或缺乏β2-6果聚糖结合活性的单克隆抗体所表达的调节性独特型表位的免疫化学和分子特征分析
J Exp Med. 1985 Aug 1;162(2):647-62. doi: 10.1084/jem.162.2.647.
3
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.来自表达A/J品系主要交叉反应独特型的BALB/c小鼠的两种抗对氨基苯砷酸单克隆抗体的重链可变区的完整氨基酸序列。
J Exp Med. 1984 Oct 1;160(4):1070-86. doi: 10.1084/jem.160.4.1070.
4
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.利用与异常重链多样性基因（DH）、重链连接基因（JH）和κ轻链可变区（Vκ）片段相关的T15重链可变区（VH），从免疫缺陷的CBA/N小鼠中获得的一种磷酸胆碱结合抗体的氨基酸序列。
J Immunol. 1984 Mar;132(3):1544-9.
5
Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes.对磷酸胆碱的免疫记忆。IV. 代表I组（T15样）和II组（非T15样）抗体的杂交瘤利用不同的VH基因。
J Immunol. 1984 Mar;132(3):1550-5.
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Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous.来自BALB/c和A/J小鼠、具有36-60独特型的抗砷酸盐单克隆抗体的完整重链和轻链可变区序列高度同源。
J Immunol. 1984 Nov;133(5):2603-9.
7
T-cell-epitope mapping of the idiotypic monoclonal IgG heavy and light chains in multiple myeloma.多发性骨髓瘤中独特型单克隆IgG重链和轻链的T细胞表位图谱分析
Int J Cancer. 1999 Mar 1;80(5):671-80. doi: 10.1002/(sici)1097-0215(19990301)80:5<671::aid-ijc7>3.0.co;2-e.
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Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodies.重链可变区。多个基因片段编码抗4-（羟基-3-硝基苯基）乙酰独特型抗体。
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9
The association of various D elements with a single-immunoglobulin VH gene segment: influence on the expression of a major cross-reactive idiotype.各种D元件与单个免疫球蛋白VH基因片段的关联：对主要交叉反应独特型表达的影响。
J Immunol. 1985 Feb;134(2):1236-44.
10
Amino acid sequence of the heavy chain variable region from the A/J mouse anti-arsonate monoclonal antibody 36-60 bearing a minor idiotype.携带一种次要独特型的A/J小鼠抗砷酸盐单克隆抗体36-60重链可变区的氨基酸序列。
Biochemistry. 1983 Aug 30;22(18):4291-6. doi: 10.1021/bi00287a020.

引用本文的文献

1
Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids.针对多糖荚膜的天然抗体使库普弗细胞能够在肝血窦中捕获入侵的细菌。
J Exp Med. 2025 Feb 3;222(2). doi: 10.1084/jem.20240735. Epub 2024 Dec 24.
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Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.利用VH4-21基因片段对人免疫球蛋白上一种交叉反应性独特型表位进行分子特征分析。
J Exp Med. 1993 Oct 1;178(4):1419-28. doi: 10.1084/jem.178.4.1419.
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Molecular characteristics of anti-polysaccharide antibodies.抗多糖抗体的分子特征。
Springer Semin Immunopathol. 1993;15(2-3):103-18. doi: 10.1007/BF00201095.
4
Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.从人脾脏RNA中分离生发中心样事件。与IgM、IgG和IgA共同表达的克隆相关VH6DJH重排的体细胞超突变。
J Clin Invest. 1993 Apr;91(4):1838-42. doi: 10.1172/JCI116397.
5
Sequence similarities among kappa IIIb chains of monoclonal human IgM kappa autoantibodies.单克隆人IgMκ自身抗体的κIIIb链之间的序列相似性。
J Exp Med. 1984 Sep 1;160(3):893-904. doi: 10.1084/jem.160.3.893.
6
Somatic diversification of immunoglobulins.免疫球蛋白的体细胞多样化
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2162-6. doi: 10.1073/pnas.81.7.2162.
7
VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules.编码针对β-(1,6)-半乳聚糖免疫应答的VH基因：IgM分子中的体细胞突变
EMBO J. 1984 Dec 1;3(12):3023-30. doi: 10.1002/j.1460-2075.1984.tb02249.x.
8
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype.与人单克隆IgM类风湿因子重链第三高变区相对应的合成肽确定了一个免疫显性独特型。
J Exp Med. 1985 Aug 1;162(2):756-61. doi: 10.1084/jem.162.2.756.
9
Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.前B细胞系中免疫球蛋白重链基因座的高突变
Proc Natl Acad Sci U S A. 1985 Jan;82(2):479-82. doi: 10.1073/pnas.82.2.479.
10
Idiotypic self binding of a dominant germline idiotype (T15). Autobody activity is affected by antibody valency.优势种系独特型（T15）的独特型自身结合。自身抗体活性受抗体价的影响。
J Exp Med. 1987 May 1;165(5):1332-43. doi: 10.1084/jem.165.5.1332.

本文引用的文献

1
Immunological relationships among the myeloma proteins.骨髓瘤蛋白之间的免疫学关系。
J Exp Med. 1955 Jan 1;101(1):85-108. doi: 10.1084/jem.101.1.85.
2
A monoclonal antibody that defines an idiotope with two subsites in galactan-binding myeloma proteins.一种单克隆抗体，它能识别半乳聚糖结合性骨髓瘤蛋白中具有两个亚位点的独特型表位。
J Exp Med. 1981 Dec 1;154(6):1946-56. doi: 10.1084/jem.154.6.1946.
3
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.杂交瘤细胞中的免疫球蛋白V区变体。II. V基因之间的重组
EMBO J. 1982;1(5):635-40. doi: 10.1002/j.1460-2075.1982.tb01220.x.
4
Polymorphism in immunoglobulin heavy chains suggesting gene conversion.免疫球蛋白重链中的多态性提示基因转换。
Proc Natl Acad Sci U S A. 1982 May;79(10):3280-4. doi: 10.1073/pnas.79.10.3280.
5
kappa-Chain restriction in anti-galactan antibodies.抗半乳聚糖抗体中的κ链限制
J Immunol. 1982 Aug;129(2):615-8.
6
Single amino acid substitution altering antigen-binding specificity.单个氨基酸取代改变抗原结合特异性。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1979-83. doi: 10.1073/pnas.79.6.1979.
7
Somatic mutation in a cultured mouse myeloma cell affects antigen binding.培养的小鼠骨髓瘤细胞中的体细胞突变会影响抗原结合。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1240-4. doi: 10.1073/pnas.79.4.1240.
8
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.免疫球蛋白重链多样性DNA片段的组织、结构与组装
J Exp Med. 1982 Jan 1;155(1):201-18. doi: 10.1084/jem.155.1.201.
9
The complete V domain amino acid sequences of two myeloma inulin-binding proteins.两种骨髓瘤菊粉结合蛋白的完整V结构域氨基酸序列。
J Immunol. 1982 Jan;128(1):302-7.
10
Mouse heavy chain variable regions: nucleotide sequence of a germ-line VH gene segment.小鼠重链可变区：种系VH基因片段的核苷酸序列
Nucleic Acids Res. 1981 Aug 25;9(16):4099-109. doi: 10.1093/nar/9.16.4099.

半乳聚糖结合抗体。独特型的多样性与结构。

Galactan-binding antibodies. Diversity and structure of idiotypes.

作者信息

Rudikoff S, Pawlita M, Pumphrey J, Mushinski E, Potter M

出版信息

J Exp Med. 1983 Nov 1;158(5):1385-400. doi: 10.1084/jem.158.5.1385.

DOI:10.1084/jem.158.5.1385
PMID:6195282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187133/
Abstract

A group of eight IgM hybridoma proteins induced with beta(1,6)-D-galactan-containing antigens has been characterized in terms of primary amino acid sequence and idiotype expression. The H chain amino acid sequences reveal very strong homology in the VH segment although several substitutions are seen that suggest the occurrence of somatic mutation in these IgM molecules. Significant sequence variation was observed in CDR-3, the region generated by the D segment, and the two recombination events, VH-D and D-JH. The number of amino acids in this region contributed by the D segment was found to vary from two to six, yet the overall length of CDR-3 was precisely maintained by the addition of amino acids on either side of D during the recombination processes. These additional amino acids are suggested to result from nucleotide addition by repair enzymes. Idiotypic analysis of these proteins, in conjunction with an assessment of the H chain sequences, has permitted an identification of the molecular basis of both cross-reacting and unique idiotypic determinants expressed by these molecules.

摘要

一组由含β(1,6)-D-半乳聚糖抗原诱导产生的八种IgM杂交瘤蛋白，已在一级氨基酸序列和独特型表达方面进行了表征。重链氨基酸序列在VH区段显示出很强的同源性，尽管可以看到一些取代，这表明这些IgM分子中发生了体细胞突变。在CDR-3、由D区段产生的区域以及两个重组事件VH-D和D-JH中观察到了显著的序列变异。发现D区段贡献的该区域氨基酸数量从两个到六个不等，但在重组过程中，通过在D两侧添加氨基酸，CDR-3的总长度得以精确维持。这些额外的氨基酸被认为是由修复酶添加核苷酸所致。对这些蛋白的独特型分析，结合重链序列评估，使得能够鉴定这些分子所表达的交叉反应性和独特独特型决定簇的分子基础。