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相似文献

1
Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.一种独特型抗体的特性。一种抗独特型抗体，它既能与类风湿因子（RF）的独特型反应，又能与RF识别的抗原反应。
J Exp Med. 1985 Feb 1;161(2):323-31. doi: 10.1084/jem.161.2.323.
2
Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides.用合成高变区肽诱导产生的七种抗独特型抗体对人类风湿因子的特性鉴定
J Exp Med. 1985 Aug 1;162(2):487-500. doi: 10.1084/jem.162.2.487.
3
The common occurrence of internal image type anti-idiotypic antibodies in rabbits immunized with monoclonal and polyclonal human IgM rheumatoid factors.在用单克隆和多克隆人IgM类风湿因子免疫的兔子中，内部图像型抗独特型抗体的常见出现情况。
Clin Exp Immunol. 1986 Jun;64(3):570-80.
4
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype.与人单克隆IgM类风湿因子重链第三高变区相对应的合成肽确定了一个免疫显性独特型。
J Exp Med. 1985 Aug 1;162(2):756-61. doi: 10.1084/jem.162.2.756.
5
Modulation of human rheumatoid factor-specific lymphocyte responses with a cross-reactive anti-idiotype bearing the internal image of antigen.携带抗原内影像的交叉反应性抗独特型对人类风湿因子特异性淋巴细胞反应的调节作用。
J Immunol. 1984 Mar;132(3):1183-9.
6
The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors.针对人类类风湿因子的交叉反应性抗独特型抗体中IgG的内部影像。
J Immunol. 1983 Aug;131(2):719-24.
7
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.用人抗合成肽抗体描绘人自身抗体上的交叉反应独特型。
J Exp Med. 1984 May 1;159(5):1502-11. doi: 10.1084/jem.159.5.1502.
8
A monoclonal anti-idiotype specific for human polyclonal IgM rheumatoid factor.一种针对人多克隆IgM类风湿因子的单克隆抗独特型抗体。
J Immunol. 1992 Jun 15;148(12):3873-8.
9
Epibody: the image of the network created by a single antibody.表位体：由单个抗体产生的网络图像。
Immunol Rev. 1986 Apr;90:115-27. doi: 10.1111/j.1600-065x.1986.tb01480.x.
10
Epibodies in autoimmunity: antisera against autoantibodies to the renal glomerular basement membrane react with idiotypes as well as with autoantigens.自身免疫中的表位抗体：抗肾小球基底膜自身抗体的抗血清与独特型以及自身抗原发生反应。
Autoimmunity. 1989;5(1-2):3-16. doi: 10.3109/08916938909029138.

引用本文的文献

1
Antibodies with idiotypic and anti-idiotypic reactivity (epibodies) in conventional immune responses to dinitrophenylated carriers.在对二硝基苯基化载体的传统免疫反应中具有独特型和抗独特型反应性的抗体（表位抗体）。
Immunology. 1998 Apr;93(4):572-80. doi: 10.1046/j.1365-2567.1998.00466.x.
2
Immunoglobulin with complementary paratope and idiotope.具有互补互补位和独特型位的免疫球蛋白。
J Exp Med. 1986 Apr 1;163(4):787-96. doi: 10.1084/jem.163.4.787.
3
Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.冷沉淀类风湿因子上的交叉反应独特型
Springer Semin Immunopathol. 1988;10(1):35-55. doi: 10.1007/BF02054022.
4
Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.小鼠单克隆类风湿因子抗体克隆重链可变区基因的精细特异性、独特型及性质
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8293-7. doi: 10.1073/pnas.83.21.8293.
5
Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network.MRL-lpr/lpr小鼠中的平行自身抗体组。一种抗DNA、抗SmRNP、抗gp70网络。
J Exp Med. 1987 Feb 1;165(2):483-99. doi: 10.1084/jem.165.2.483.
6
Monoclonal antibodies defining a minor and a private idiotope on human rheumatoid factors.定义人类类风湿因子上一个次要独特型和一个个体独特型的单克隆抗体。
J Clin Immunol. 1986 Sep;6(5):349-54. doi: 10.1007/BF00915373.
7
Evolutionary origin of autoreactive determinants (autogens).自身反应性决定簇（自身抗原）的进化起源。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2521-5. doi: 10.1073/pnas.83.8.2521.
8
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.大量肽快速固相合成的通用方法：单个氨基酸水平上抗原-抗体相互作用的特异性
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5131-5. doi: 10.1073/pnas.82.15.5131.
9
Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides.用合成高变区肽诱导产生的七种抗独特型抗体对人类风湿因子的特性鉴定
J Exp Med. 1985 Aug 1;162(2):487-500. doi: 10.1084/jem.162.2.487.
10
Human IgG anti-F(ab')2 antibodies possess rheumatoid factor activity.人IgG抗F(ab')2抗体具有类风湿因子活性。
Clin Exp Immunol. 1990 Aug;81(2):293-300. doi: 10.1111/j.1365-2249.1990.tb03333.x.

本文引用的文献

1
Individual Antigenic Specificity of Isolated Antibodies.分离抗体的个体抗原特异性
Science. 1963 Jun 14;140(3572):1218-9. doi: 10.1126/science.140.3572.1218.
2
Immunological relationships among the myeloma proteins.骨髓瘤蛋白之间的免疫学关系。
J Exp Med. 1955 Jan 1;101(1):85-108. doi: 10.1084/jem.101.1.85.
3
The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors.针对人类类风湿因子的交叉反应性抗独特型抗体中IgG的内部影像。
J Immunol. 1983 Aug;131(2):719-24.
4
Rheumatoid factors and secondary immune responses in the mouse. II. Incidence, kinetics and induction mechanisms.小鼠中的类风湿因子与二次免疫反应。II. 发生率、动力学及诱导机制。
Eur J Immunol. 1983 Nov;13(11):895-9. doi: 10.1002/eji.1830131107.
5
Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens.小鼠中的类风湿因子与次级免疫反应。I. 用蛋白质抗原免疫后，频繁出现分泌IgM抗IgG1自身抗体的杂交瘤。
Eur J Immunol. 1983 Nov;13(11):890-4. doi: 10.1002/eji.1830131106.
6
Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.小鼠类风湿抗体的诱导。次级体液反应中自身抗体的调节性产生。
J Exp Med. 1983 Aug 1;158(2):529-45. doi: 10.1084/jem.158.2.529.
7
A common idiotope on human rheumatoid factors identified by a hybridoma antibody.一种由杂交瘤抗体识别的人类类风湿因子上的常见独特型。
Mol Immunol. 1983 Oct;20(10):1081-7. doi: 10.1016/0161-5890(83)90116-5.
8
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide.用人抗合成肽抗体描绘人自身抗体上的交叉反应独特型。
J Exp Med. 1984 May 1;159(5):1502-11. doi: 10.1084/jem.159.5.1502.
9
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes.由特定肽诱导产生的抗高变区抗体：一种研究独特型结构相关性的方法。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1784-8. doi: 10.1073/pnas.81.6.1784.
10
Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies.κIIIb轻链与单克隆人IgMκ自身抗体的优先缔合。
J Immunol. 1983 Sep;131(3):1322-5.

一种独特型抗体的特性。一种抗独特型抗体，它既能与类风湿因子（RF）的独特型反应，又能与RF识别的抗原反应。

Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.

作者信息

Chen P P, Fong S, Houghten R A, Carson D A

出版信息

J Exp Med. 1985 Feb 1;161(2):323-31. doi: 10.1084/jem.161.2.323.

DOI:10.1084/jem.161.2.323
PMID:3919139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187561/
Abstract

Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.

摘要

最近，发现一种针对人单克隆IgM抗IgG自身抗体（类风湿因子）的抗独特型抗体也能与人IgG发生反应。这种特殊的抗独特型抗体被称为“表位抗体”。我们描述了用一种合成肽（对应于IgM类风湿因子Glo的一个高变区）免疫诱导出类似表位抗体的过程。这些结果证实了表位抗体的存在，并为表位抗体现象提供了可能的分子基础。