一种独特型抗体的特性。一种抗独特型抗体，它既能与类风湿因子（RF）的独特型反应，又能与RF识别的抗原反应。
Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.
作者信息
Chen P P, Fong S, Houghten R A, Carson D A
出版信息
J Exp Med. 1985 Feb 1;161(2):323-31. doi: 10.1084/jem.161.2.323.
Abstract
Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.
摘要
最近，发现一种针对人单克隆IgM抗IgG自身抗体（类风湿因子）的抗独特型抗体也能与人IgG发生反应。这种特殊的抗独特型抗体被称为“表位抗体”。我们描述了用一种合成肽（对应于IgM类风湿因子Glo的一个高变区）免疫诱导出类似表位抗体的过程。这些结果证实了表位抗体的存在，并为表位抗体现象提供了可能的分子基础。
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Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.一种独特型抗体的特性。一种抗独特型抗体，它既能与类风湿因子（RF）的独特型反应，又能与RF识别的抗原反应。
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