State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Eur J Med Chem. 2024 Dec 5;279:116850. doi: 10.1016/j.ejmech.2024.116850. Epub 2024 Sep 6.
In recent years, the number of cancers has soared, becoming one of the leading causes of human death. At the same time, marine anticancer substances have been the focus of marine drug research. Marine alkaloids derived from marine invertebrates like sponges are an important class of secondary metabolites, which have good bioactivities of blocking the cancer cell cycle, inducing autophagy and apoptosis of cancer cells, inhibiting cancer cell invasion and proliferation. They show potential as anticancer drug candidates. Therefore, in this review, we focus on the detailed introduction of bioactive alkaloids and their synthetic analogs from marine invertebrates, such as 4-chloro fascapysin and other 41 kinds of marine alkaloids or marine alkaloid synthetic analogs. They have significant anticancer activities on breast cancer, cervical cancer, colorectal cancer, prostate cancer, lung cancer, liver cancer, and so on. It provides new candidate compounds for anticancer drug research and provides a reference basis for marine drug resources research.
近年来，癌症的发病率飙升，成为人类死亡的主要原因之一。与此同时，海洋抗癌物质一直是海洋药物研究的重点。海洋生物碱是海洋无脊椎动物（如海绵）的一种重要次生代谢产物，具有阻断癌细胞周期、诱导癌细胞自噬和凋亡、抑制癌细胞侵袭和增殖等良好的生物活性，有望成为抗癌药物的候选物。因此，在本文综述中，我们重点介绍了来自海洋无脊椎动物的具有生物活性的生物碱及其合成类似物，如 4-氯 fascapysin 和其他 41 种海洋生物碱或海洋生物碱合成类似物。它们对乳腺癌、宫颈癌、结直肠癌、前列腺癌、肺癌、肝癌等具有显著的抗癌活性。为抗癌药物研究提供了新的候选化合物，为海洋药物资源研究提供了参考依据。
