Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, China.
Department of Vascular and Thyroid Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China.
Eur J Med Chem. 2024 Dec 5;279:116798. doi: 10.1016/j.ejmech.2024.116798. Epub 2024 Aug 27.
The technique of antimicrobial therapy action is to stop or slow the growth of bacteria that can kill people, animals, and crops. The most widely used antibacterial agents are antibiotics. Even though these antimicrobial medications are quite effective, there are still certain barriers or challenges in using them effectively. To solve these issues, new antimicrobial drug molecules that don't have side effects or resistance are needed. These days, antimicrobial drugs placed in nanosized vehicles, or nanomedicine, made of different metal and metallic oxides as well as of polymer, carbon or lipid-based may be used to address these issues with conventional therapy and delivery techniques. This review focuses on the importance of nanotechnology in antimicrobial therapy, nanoparticles (NPs) used in this therapy, their mode of action, and the recent advancement in nanotechnology for antimicrobial therapy.
抗菌治疗技术旨在阻止或减缓可能导致人类、动物和农作物死亡的细菌的生长。最广泛使用的抗菌剂是抗生素。尽管这些抗菌药物非常有效,但在有效使用它们方面仍然存在一定的障碍或挑战。为了解决这些问题,需要新的具有副作用小或耐药性的抗菌药物分子。如今,可将抗菌药物置于纳米尺寸的载体中,即纳米医学,可采用不同的金属和金属氧化物以及聚合物、碳或基于脂质的材料来解决传统治疗和输送技术中存在的这些问题。本综述重点介绍了纳米技术在抗菌治疗中的重要性、该治疗中使用的纳米粒子(NPs)、它们的作用模式以及纳米技术在抗菌治疗方面的最新进展。