Kanon Alexander P, Spies Sarah J, MacGibbon Alastair K H, Fuad Maher
Fonterra Research and Development Centre, Private Bag 11029, Dairy Farm Road, Palmerston North 4472, New Zealand.
Foods. 2024 Aug 28;13(17):2725. doi: 10.3390/foods13172725.
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with dyslipidemia being a significant risk factor. This meta-analysis provides a comprehensive evaluation of the impact of bovine dairy-derived milk fat globule membrane (MFGM) supplementation on blood lipid profiles in adults. A systematic search was conducted across various databases up until March 2024, resulting in the inclusion of 6 trials with a total of 464 participants. The findings indicated that MFGM phospholipid supplementation may significantly reduce total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol levels. A combined analysis of the effects on TC, LDL, and triglycerides (TG) revealed a significant overall reduction in these markers. However, no significant increase or reduction was observed on high-density lipoprotein (HDL) and TG levels. Overall, MFGM phospholipid intake may significantly decrease the level of TC and LDL, while no significant changes in TG and HDL were observed. These results suggest that MFGM supplementation could be a promising dietary intervention for improving lipid profiles in adults. Nonetheless, further research is warranted to confirm these results and to better understand the potential variability in the impact of MFGM on blood lipid levels.
心血管疾病（CVDs）是全球范围内导致死亡的主要原因，血脂异常是一个重要的危险因素。这项荟萃分析全面评估了补充源自牛乳的乳脂肪球膜（MFGM）对成年人血脂谱的影响。截至2024年3月，在多个数据库中进行了系统检索，纳入了6项试验，共有464名参与者。研究结果表明，补充MFGM磷脂可能会显著降低总胆固醇（TC）和低密度脂蛋白（LDL）胆固醇水平。对TC、LDL和甘油三酯（TG）影响的综合分析显示，这些指标总体上有显著降低。然而，高密度脂蛋白（HDL）和TG水平未观察到显著升高或降低。总体而言，摄入MFGM磷脂可能会显著降低TC和LDL水平，而TG和HDL未观察到显著变化。这些结果表明，补充MFGM可能是一种有前景的饮食干预措施，可改善成年人的血脂谱。尽管如此，仍需进一步研究来证实这些结果，并更好地了解MFGM对血脂水平影响的潜在变异性。
