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提取物（L.）通过减轻炎症和调节皮肤微生物群促进斑秃小鼠的毛发生长。

extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota.

作者信息

Guan Tangfei, Yang Xin, Hong Canhui, Zhu Jiali, Xiao Peiyun, Yang Yongshou, Zhang Chenggui, He Zhengchun

机构信息

Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, China.

National-Local Joint Engineering Research Center of Entomoceutics, Dali, China.

出版信息

Front Pharmacol. 2025 Aug 6;16:1590648. doi: 10.3389/fphar.2025.1590648. eCollection 2025.

DOI:10.3389/fphar.2025.1590648
PMID:40843376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12365694/
Abstract

INTRODUCTION

Alopecia areata (AA), an autoimmune hair-loss disease due to follicular inflammatory cell infiltration, lacks an ideal cure. The Periplaneta Americana (PA) extract (PA-011), a traditional Chinese medicine with anti-inflammatory, antioxidant, tissue-repair-promoting, and immune-regulating properties, was studied for its AA-treating effects.

METHODS

Guided by network pharmacology, AA model mice were treated with PA-011. Hair growth, skin tissue, inflammatory factors, and Wnt protein levels were examined. Transcriptomics, metabolomics, and 16S rRNA sequencing explored the hair-growth-promoting mechanisms.

RESULTS

Network pharmacology showed PA-011 could regulate AA-related targets and pathways. PA-011 intervention promoted hair follicle cell proliferation and hair growth in AA mice, reduced skin TNF-α, IL-23, and VCAM-1 expression. Transcriptomics and WB analysis indicated PA-011 downregulated inflammatory genes, activated Wnt3a, and modulated the TGF-β pathway. Metabolomics found PA-011 regulated metabolic pathways. 16S rRNA analysis showed it reversed AA-induced skin microbiota changes, inhibiting pathogens and promoting probiotics. Multi-omics analysis revealed PA-011 regulated skin microbiota and metabolic balance for hair growth.

DISCUSSION

In conclusion, PA-011 alleviates AA by reducing skin inflammation and modulating skin microbiota, suggesting its potential as an AA therapeutic.

摘要

引言

斑秃（AA）是一种由于毛囊炎性细胞浸润导致的自身免疫性脱发疾病，目前缺乏理想的治疗方法。美洲大蠊提取物（PA-011）是一种具有抗炎、抗氧化、促进组织修复和免疫调节特性的传统中药，本研究对其治疗斑秃的效果进行了探究。

方法

在网络药理学的指导下，用PA-011对斑秃模型小鼠进行治疗。检测毛发生长、皮肤组织、炎性因子和Wnt蛋白水平。通过转录组学、代谢组学和16S rRNA测序探索促进毛发生长的机制。

结果

网络药理学显示PA-011可调节与斑秃相关的靶点和通路。PA-011干预可促进斑秃小鼠毛囊细胞增殖和毛发生长，降低皮肤肿瘤坏死因子-α（TNF-α）、白细胞介素-23（IL-23）和血管细胞黏附分子-1（VCAM-1）的表达。转录组学和蛋白质免疫印迹分析表明，PA-011可下调炎性基因，激活Wnt3a，并调节转化生长因子-β（TGF-β）通路。代谢组学发现PA-011可调节代谢通路。16S rRNA分析显示，它可逆转斑秃引起的皮肤微生物群变化，抑制病原体并促进益生菌生长。多组学分析表明，PA-011通过调节皮肤微生物群和代谢平衡来促进毛发生长。

讨论

总之，PA-011通过减轻皮肤炎症和调节皮肤微生物群来缓解斑秃，表明其作为斑秃治疗药物的潜力。

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