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纳米技术在淋巴恶性肿瘤的检测和治疗中的进展。

Nanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies.

机构信息

Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06132 Perugia, Italy.

Department of Medicine and Surgery, Biosciences and Medical Embryology Section, University of Perugia, 06132 Perugia, Italy.

出版信息

Int J Mol Sci. 2024 Aug 26;25(17):9253. doi: 10.3390/ijms25179253.

Abstract

Lymphoid malignancies are complex diseases with distinct biological behaviors, clinical presentations, and treatment responses. Ongoing research and advancements in biotechnology enhance the understanding and management of these malignancies, moving towards more personalized approaches for diagnosis and treatment. Nanotechnology has emerged as a promising tool to improve some limitations of conventional diagnostics as well as treatment strategies for lymphoid malignancies. Nanoparticles (NPs) offer unique advantages such as enhanced multimodal detection, drug delivery, and targeted therapy capabilities, with the potential to improve precision medicine and patient outcomes. Here, we comprehensively examine the current landscape of nanoconstructs applied in the management of lymphoid disease. Through a comprehensive analysis of preclinical studies, we highlight the translational potential of NPs in revolutionizing the field of hematological malignancies, with a specific focus on lymphoid neoplasms.

摘要

淋巴恶性肿瘤是一种具有独特生物学行为、临床表现和治疗反应的复杂疾病。生物技术的不断研究和进步提高了对这些恶性肿瘤的认识和管理水平,使诊断和治疗更加个性化。纳米技术已成为改善传统诊断方法以及淋巴恶性肿瘤治疗策略局限性的一种有前途的工具。纳米颗粒 (NPs) 具有独特的优势,例如增强的多模态检测、药物输送和靶向治疗能力,有可能改善精准医学和患者的治疗效果。在这里,我们全面研究了应用于淋巴疾病管理的纳米结构的当前情况。通过对临床前研究的全面分析,我们强调了 NPs 在彻底改变血液恶性肿瘤领域的潜力,特别是在淋巴肿瘤方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd1d/11395233/4b7de2487d52/ijms-25-09253-g001.jpg

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